| Company Name: |
Shanghai Run-Biotech Co., Ltd.
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| Tel: |
021-57171705 13817537615 |
| Email: |
sales@run-biotech.com |
| Products Intro: |
Product Name:2-Chloro-1-ethyl-1h-benzo[d]imidazole
CAS:58533-15-6
Purity:97% Package:25g/50g
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| | 1H-Benzimidazole,2-chloro-1-ethyl-(9CI) Basic information |
| | 1H-Benzimidazole,2-chloro-1-ethyl-(9CI) Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | White to off-white Solid |
| | 1H-Benzimidazole,2-chloro-1-ethyl-(9CI) Usage And Synthesis |
| Synthesis | General method: 2-chloro-1H-benzimidazole (3.04 g, 20 mmol) was dissolved in anhydrous N,N-dimethylformamide (DMF, 15 mL) at 0 °C. Sodium hydride (NaH, 60% dispersed in mineral oil, 0.91 g, 22.7 mmol) was slowly added to this solution and the reaction mixture was stirred at 0 °C for 1 hour. Subsequently, ethyl bromide (21.6 mmol) was added dropwise. The reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, the mixture was poured into water (50 mL) and stirring was continued for 1 hour. The precipitate was collected by filtration, washed well with water and dried under vacuum to afford the target products 2-chloro-1-ethyl-1H-benzo[d]imidazole (4a-d). | | References | [1] Zeitschrift fur Anorganische und Allgemeine Chemie, 2013, vol. 639, # 14, p. 2450 - 2454
[2] European Journal of Medicinal Chemistry, 2011, vol. 46, # 1, p. 417 - 422
[3] European Journal of Medicinal Chemistry, 2010, vol. 45, # 3, p. 909 - 914 |
| | 1H-Benzimidazole,2-chloro-1-ethyl-(9CI) Preparation Products And Raw materials |
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