| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:GA 0113 CAS:200639-61-8 Package:50mg
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| | N-[2-[6-[(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-2-quinolinyl]phenyl]-1,1,1-trifluoromethanesulfonamide Basic information |
| | N-[2-[6-[(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-2-quinolinyl]phenyl]-1,1,1-trifluoromethanesulfonamide Chemical Properties |
| Melting point | 252.0 °C | | Boiling point | 691.6±65.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | | pka | 2.35±0.10(Predicted) |
| | N-[2-[6-[(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-2-quinolinyl]phenyl]-1,1,1-trifluoromethanesulfonamide Usage And Synthesis |
| Uses | GA 0113 is a potent and orally active angiotensin II (Ang II) AT1-receptor antagonist. GA 0113 inhibits the Ang II (HY-13948)-induced pressor response with ID50 of 0.032 mg/kg and dose-dependently increases plasma renin activity for 48 h[1]. | | References | [1] Ebisu H, et al. Pharmacologic profiles of GA0113, a novel quinoline derivative angiotensin II AT1-receptor antagonist. J Cardiovasc Pharmacol. 1999 Oct;34(4):526-32. DOI:10.1097/00005344-199910000-00008 |
| | N-[2-[6-[(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-2-quinolinyl]phenyl]-1,1,1-trifluoromethanesulfonamide Preparation Products And Raw materials |
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