| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:FR 113680
CAS:126088-92-4
Package:100mg;500mg
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:FR 113680
CAS:126088-92-4
|
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| | FR 113680 Basic information |
| Product Name: | FR 113680 | | Synonyms: | FR 113680;L-Phenylalaninamide, N-acetyl-L-threonyl-1-formyl-D-tryptophyl-N-methyl-N-(phenylmethyl)- | | CAS: | 126088-92-4 | | MF: | C35H39N5O6 | | MW: | 625.71 | | EINECS: | | | Product Categories: | | | Mol File: | 126088-92-4.mol |  |
| | FR 113680 Chemical Properties |
| density | 1.25±0.1 g/cm3(Predicted) | | pka | 13.02±0.46(Predicted) | | Sequence | Ac-Thr-{d-Trp(For)}-{Phe(NMe,Bzl)} |
| | FR 113680 Usage And Synthesis |
| Description | FR 113680 is a novel tripeptide substance P antagonist with NK1 receptor selectivity. The inhibitory effect of FR 113680 on SP-induced guinea-pig ileum contraction is competitive and the pA2 value is 7.53. It suggest that FR 113680 interacts selectively with the NK1 neurokinin receptor. | | Uses | FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor[1]. | | in vivo | FR 113680 (32 mg/kg; i.v.; once) significantly inhibits cigarette smoke-induced plasma extravasation[2]. | Animal Model: | Male Wistar rats, cigarette smoke-induced rat tracheal plasma extravasation model[2] | | Dosage: | 0, 10 and 32 mg/kg | | Administration: | IV, once | | Result: | Significantly inhibited cigarette smoke-induced rat tracheal plasma extravasation at a dose of 32 mg/kg. |
| | References | [1] Morimoto H, et al. FR 113680: a novel tripeptide substance P antagonist with NK1 receptor selectivity. Br J Pharmacol. 1992 May;106(1):123-6. DOI:10.1111/j.1476-5381.1992.tb14303.x
[2] Morimoto H, et al. Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation. Eur J Pharmacol. 1992 Nov 24;224(1):1-5. DOI:10.1016/0014-2999(92)94810-i |
| | FR 113680 Preparation Products And Raw materials |
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