BAI1
| 中文名稱 | BAI1 |
|---|---|
| 中文同義詞 | 1-(3,6-二溴-9H-咔唑-9-基)-3-(哌嗪-1-基)丙-2-醇;3,6-二溴吲哚-ALPHA-(1-哌嗪甲基)-9H-咔唑-9-乙醇雙鹽酸鹽;化合物BAI1;化合物BAI1,10 MM DMSO 溶液 |
| 英文名稱 | 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE |
| 英文同義詞 | Baxchannelblocker2HCl;3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE;3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanoldihydrochloride;Bax channel blocke;Bax channel blocker(BAI-1);1-(3,6-Dibromo-9H-carbazoL;9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-;)-3-(piperazin-1-yL |
| CAS號(hào) | 335165-68-9 |
| 分子式 | C19H21Br2N3O |
| 分子量 | 467.2 |
| EINECS號(hào) | |
| 相關(guān)類別 | Caspases/Apoptosis;Apoptosis Inhibitors |
| Mol文件 | 335165-68-9.mol |
| 結(jié)構(gòu)式 |  |
BAI1 性質(zhì)
| 沸點(diǎn) | 388.1±42.0 °C(Predicted) |
|---|---|
| 密度 | 1.71±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Keep in dark place,Inert atmosphere,Room temperature |
| 溶解度 | 超聲波檢測(cè)下 DMSO 中≥28.2 mg/mL；不溶于乙醇；不溶于水 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 14.48±0.20(Predicted) |
| 顏色 | 白色 |
| InChI | InChI=1S/C19H21Br2N3O.2ClH/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23;;/h1-4,9-10,15,22,25H,5-8,11-12H2;2*1H |
| InChIKey | HWFKCAFKXZFOQT-UHFFFAOYSA-N |
| SMILES | C12=CC=C(Br)C=C1C1=C(C=CC(Br)=C1)N2CC(O)CN1CCNCC1.Cl.Cl |
BAI1是一種直接的BAX變構(gòu)抑制劑，Kd值為15.0 ± 4 μM。
| Target | Value |
|
Bax
(Cell-free assay) | 15.0 μM(Kd) |
BAI1 selectively inhibits BAX-mediated apoptotic cell death.
BAI1 shows inhibition of tBID (HY-100464)-induced BAX-mediated membrane permeabilization in a dose dependent manner with an IC
50
of 3.3 μΜ.
Apoptosis Analysis
| Cell Line: | Mouse MEF |
| Concentration: | 0.3125 μM , 0.625 μM, 1 μM, 1.25 μM, 1.5 μM, 2.5 μM , 3 μM, 4 μM, 5 4 μM, 10 4 μM |
| Incubation Time: | 8 hours |
| Result: | Inhibited cell death in BAX-dependent manner. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-103269 | BAI1 BAI1 | 335165-68-9 | 1 mg | 400元 |
| 2026/06/05 | HY-103269 | BAI1 BAI1 | 335165-68-9 | 5 mg | 800元 |