(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
| 中文名稱 | (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol |
|---|---|
| 中文同義詞 | 化合物 T23620;化合物 ACOLBIFENE HYDROCHLORIDE |
| 英文名稱 | (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol |
| 英文同義詞 | ACOLBIFENE (hydrochloride);(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol;BYQDPIXWTVEVEA-JMAPEOGHSA-N;(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol,hydrochloride |
| CAS號(hào) | 252555-01-4 |
| 分子式 | C29H31NO4 |
| 分子量 | 0 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 252555-01-4.mol |
| 結(jié)構(gòu)式 | ![(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 結(jié)構(gòu)式](CAS/GIF/252555-01-4.gif) |
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol 性質(zhì)
| 溶解度 | 二甲基亞砜：180 mg/ml（364.36 mM） |
|---|---|
| 形態(tài) | 固體 |
| 顏色 | 白色至黃色 |
|
Estrogen receptor 0.110 nM (IC 50 ) |
Acolbifene (ACOL) does not affect pathways of cholesterol synthesis, supporting the involvement of the clearance-related receptors in its hypocholesterolemic action.
Acolbifene (EM-652) shows no agonistic activity on ERα and ERβ transcriptional function and blocks the estradiol (E2)-mediated activation of both ERα and ERβ.
Acolbifene (EM-652) shows the most potent inhibition of estradiol-stimulated cell proliferation in human breast cancer cells (ZR-75-1, MCF-7, T-47D) and is devoid of any intrinsic estrogenic activity.
Acolbifene (ACOL) reduces food intake and strongly decreases cholesterolemia in rats fed a cholesterol-free diet.
Acolbifene (ACOL) reduces food intake (16%) and weight gain (45%, mainly fat) similarly in both dietary cohorts.
| Animal Model: | Female Sprague-Dawley rats (n = 42) initially weighing 175-200 g. |
| Dosage: | 2.5 mg/kg. |
| Administration: | Oral gavage, once daily for 21 d. |
| Result: | Prevents tumor growth in rats. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-16023 | (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol Acolbifene hydrochloride | 252555-01-4 | 5mg | 1800元 |
| 2026/06/05 | HY-16023 | (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol Acolbifene hydrochloride | 252555-01-4 | 10mg | 2900元 |