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| | 5-BROMO-6-METHYL-1H-INDAZOLE Basic information | | Uses |
| | 5-BROMO-6-METHYL-1H-INDAZOLE Chemical Properties |
| Melting point | 166-169°C | | Boiling point | 344.6±22.0 °C(Predicted) | | density | 1.654±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | solid | | pka | 13.21±0.40(Predicted) | | Appearance | Yellow to brown Solid | | InChI | InChI=1S/C8H7BrN2/c1-5-2-8-6(3-7(5)9)4-10-11-8/h2-4H,1H3,(H,10,11) | | InChIKey | UTDBMGRTYFPTEC-UHFFFAOYSA-N | | SMILES | N1C2=C(C=C(Br)C(C)=C2)C=N1 |
| Hazard Codes | Xn | | Risk Statements | 22-51 | | WGK Germany | 3 | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 5-BROMO-6-METHYL-1H-INDAZOLE Usage And Synthesis |
| Uses | 5-Bromo-6-methyl-1H-indazole is a heterocyclic organic compound, and some literature reports that it can be used to prepare LRRK2 inhibitors. | | Synthesis | General procedure for the synthesis of 5-bromo-6-methyl-1H-indazole (compound A3) from 1-(5-bromo-6-methyl-1H-indazol-1-yl)ethanone: 1-(5-bromo-6-methyl-1H-indazol-1-yl)ethanone (3.90 g, 15.4 mmol) was suspended in methanol (12 mL) and 2.0 mol/L hydrochloric acid (39 mL). The mixture was stirred at 100 °C for 1 hour. After completion of the reaction, 10 mol/L aqueous potassium hydroxide (10 mL) was slowly added to the mixture under cooling in an ice bath. The precipitate was separated by filtration to afford the target compound 5-bromo-6-methyl-1H-indazole (compound A3, 3.20 g, yield: 97%) as colorless crystals. The product was analyzed by ESI-MS showing m/z: 211 [M + H]+; 1H-NMR (CDCl3) δ (ppm): 2.53 (s, 3H), 7.38 (d, J = 1.0 Hz, 1H), 7.96 (s, 1H), 7.98 (d, J = 1.0 Hz, 1H). | | References | [1] Patent: EP2308880, 2011, A1. Location in patent: Page/Page column 41
[2] Patent: WO2011/72488, 2011, A1. Location in patent: Page/Page column 17; 42 |
| | 5-BROMO-6-METHYL-1H-INDAZOLE Preparation Products And Raw materials |
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