奧替那班
| 中文名稱 | 奧替那班 |
|---|---|
| 中文同義詞 | 1-[9-(4-氯苯基)-8-(2-氯苯基)-9H-嘌呤-6-基]-4-乙基氨基哌啶-4-甲酰胺;奧替那班;1-(8-(2-氯苯基)-9-(4-氯苯基)-9H-嘌呤-6-基)-4-(乙氨基)哌啶-4-甲酰胺;奧替那班,10 MM DMSO 溶液;抑制劑Otenabant;抑制劑Otenabant;1-[8-(2-氯苯基)-9-(4-氯苯基)-9H-五林-6-y1]-4-(乙基氨基)-4-哌啶羧酰胺 |
| 英文名稱 | Otenabant |
| 英文同義詞 | otenabant;1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxamide;Otenabant (CP-945,598);Otenabant, >=98%;CP945598 free base;4-Piperidinecarboxamide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)-;CP 945598;OTENABANT;CP945598;CP 945598; CP-945598; CP945598 |
| CAS號(hào) | 686344-29-6 |
| 分子式 | C25H25Cl2N7O |
| 分子量 | 510.42 |
| EINECS號(hào) | |
| 相關(guān)類別 | G蛋白偶聯(lián)受體&G蛋白;醫(yī)藥 |
| Mol文件 | 686344-29-6.mol |
| 結(jié)構(gòu)式 |  |
奧替那班 性質(zhì)
| 沸點(diǎn) | 757.9±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.46 |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | DMSO：100 mg/mL（195.92 mM；需要超聲波） |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 16.30±0.20(Predicted) |
| 顏色 | 白色至米白色 |
Ki: 0.7 nM (CB1)
Otenabant HCl has low affinity with K i of 7.6 μM for human CB2 receptors. Otenabant HCl inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration.
Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. Otenabant (10 mg/kg, p.o.) promotes a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice. Otenabant HCl reverses four cannabinoid agonistmediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-10871 | 奧替那班 Otenabant | 686344-29-6 | 5mg | 500元 |
| 2026/06/05 | HY-10871 | 奧替那班 Otenabant | 686344-29-6 | 10mM * 1mLin DMSO | 561元 |