| Company Name: |
Shanghai Merlot Chemical Co., LTD
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| Tel: |
15821661757 |
| Email: |
226174156@qq.com |
| Products Intro: |
Product Name:BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-
CAS:66778-36-7
Purity:95% Package:1g；5g
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Encainide
CAS:66778-36-7
Purity:95.00% Package:2mg;5mg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Encainide
CAS:66778-36-7
Package:2mg/RMB 1540
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| | BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]- Basic information |
| | BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]- Chemical Properties |
| storage temp. | Store at -20°C | | form | Solid | | color | White to off-white |
| | BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]- Usage And Synthesis |
| Chemical Properties | Light yellow crystal. Soluble in ether, insoluble in saturated saline. Encainide Hydroehloride: C22H28N2O2HCI.[66794-74-9]. White crystal, melting point 131.5-132.5℃. Soluble in water, slightly soluble in alcohol, insoluble in ether or pentane. Acute toxicity LD50 mice, dogs (mg/kg): 86, 43 oral; 16, 17 intravenous. | | Uses | Encainide (MJ9067) is an antiarrhythmic agent with class IC activity. Encainide blocks voltage-dependent potassium channels. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research[1][2]. | | Definition | ChEBI: 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life-
hreatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market. | | in vivo | Encainide (0.3, 0.9, 2.7 mg/kg; infusion of single doses) prolongs His-Purkinje conduction time (HV interval) and intra-ventricular conduction time (QRS duration) but has no effect on sinus nodal recovery time or AV nodal conduction, or on refractoriness of atrium, AV node, or ventricular myocardium or on QT interval[1]. | | References | [1] R N Brogden, et al. Encainide. A review of its pharmacological properties and therapeutic efficacy. Drugs. 1987 Nov;34(5):519-38. DOI:10.2165/00003495-198734050-00002
[2] Hongliang Li, et al. Encainide, a class Ic anti-arrhythmic agent, blocks voltage-dependent potassium channels in coronary artery smooth muscle cells. Korean J Physiol Pharmacol. 2023 Jul 1;27(4):399-406. DOI:10.4196/kjpp.2023.27.4.399 |
| | BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]- Preparation Products And Raw materials |
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