R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Suppliers list
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Products Intro: Product Name:R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS:125941-87-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
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Products Intro: Product Name:R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
CAS:125941-87-9
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Products Intro: Product Name:SCH-23390 hydrochloride
CAS:125941-87-9
Purity:99.51% Package:1mg;33USD|2mg;46USD|5mg;71USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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CAS:125941-87-9
Purity:98% Package:5mg Remarks:V4667
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
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Products Intro: Product Name:SCH-23390 (hydrochloride)
CAS:125941-87-9
Purity:NLT 98% Remarks:MC514928

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride manufacturers
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Basic information
Product Name:R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
Synonyms:R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE;SCH 23390 HYDROCHLORIDE;R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE;(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride;SCH 23390(HCI);(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC);R(+)-SCH-23390;R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS:125941-87-9
MF:C17H18ClNOHCl
MW:324.24
EINECS:
Product Categories:Dopamine receptor;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:125941-87-9.mol
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Structure
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Chemical Properties
alpha +27～+31°(D/20℃)(c=0.5,DMF)
storage temp. protect from light
solubility H2O: >5mg/mL
form solid
color white
Optical Rotation[α]/D +32.1°, c = 1 in DMF(lit.)
Water Solubility water: 100mM
InChI1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
InChIKeyOYCAEWMSOPMASE-XFULWGLBSA-N
SMILESCl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
EPA Substance Registry System(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride (125941-87-9)
Safety Information
WGK Germany 3
Storage Class13 - Non Combustible Solids
MSDS Information
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Usage And Synthesis
UsesR(+)-SCH-23390 hydrochloride has been used:
  • for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
  • as a D1 receptor-selective antagonist for intracranial drug infusions
  • as an antagonist of D1 receptor to study its effect on learning ability in fish

UsesA selective dopamine D1 receptor antagonist.
Biological ActivityPotent D 1 antagonist (K i values are ~ 0.2, 0.3, ~ 1100, ~ 800 and ~ 3000 nM at D 1 , D 5 , D 2 , D 3 and D 4 receptors respectively). Also an agonist at 5-HT 1C/2C receptors (K i = 6.3 nM) in vitro .
Biochem/physiol ActionsR(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.
in vivo

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D1 receptors in rodents, nonhuman primates, and humans[1].
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat[1].
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions[5].

IC 50D1 Receptor: 0.2 nM (Ki); D5 Receptor: 0.3 nM (Ki); 5-HT2C Receptor: 9.3 nM (Ki); GIRK: 268 nM (IC50)
storage+4°C (desiccate)
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Preparation Products And Raw materials
Tag:R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride(125941-87-9) Related Product Information
SCH772984 6-(p-Nitrophenyl)pyrrolo[2,1-d][1,5]benzothiazepine 5,5-dioxide SCH 58261 2-CHLORO-5-METHYLPHENOL P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE 2-(3-Chlorophenyl)ethylamine 4-Chlorophenethylamine 2-CHLORO-4,5-DIMETHYLPHENOL [2-(3-CHLORO-PHENYL)-ETHYL]-METHYL-AMINE R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride 8-CHLORO-2,3,4,5-TETRAHYDRO-5-PHENYL-1H-3-BENZAZEPIN-7-OL-(5R) 7-CHLORO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE 2-(4-CHLOROPHENYL)-2-PHENYLETHYLAMINE HYDROCHLORIDE N,N-BIS(2-PHENYLETHYL)AMINE HYDROCHLORIDE [2-(4-CHLORO-PHENYL)-ETHYL]-METHYL-AMINE N,beta-Dimethylphenethylamine hydrochloride [2-(3-CHLORO-PHENYL)-ETHYL]-ETHYL-AMINE 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPIN-7-OL