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| | 5-Bromo-4-chloro-2,6-dimethylpyrimidine Basic information |
| | 5-Bromo-4-chloro-2,6-dimethylpyrimidine Chemical Properties |
| Melting point | 45 °C | | Boiling point | 264.9±35.0 °C(Predicted) | | density | 1.621±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -0.23±0.39(Predicted) | | Appearance | White to off-white Solid |
| | 5-Bromo-4-chloro-2,6-dimethylpyrimidine Usage And Synthesis |
| Synthesis | (b) Synthesis of 5-bromo-4-chloro-2,6-dimethylpyrimidine. 5-Bromo-2,6-dimethylpyrimidin-4-ol (3.95 g, 19.45 mmol) was mixed with phosphorochloridic acid (6 mL, 64.4 mmol) and heated to reflux for 3 h at 110 °C. The reaction was carried out at a pressure of 1.5 °F. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure, followed by the slow and careful addition of ice water to precipitate a white precipitate. The solid was collected by filtration, washed thoroughly with cold water and dried to afford the target product 5-bromo-4-chloro-2,6-dimethylpyrimidine (2.73 g, 63% yield). The product was analyzed by LCMS (ES+), m/e 221 [M+H]+. | | References | [1] Patent: WO2013/96151, 2013, A1. Location in patent: Page/Page column 131
[2] Patent: US2016/176882, 2016, A1. Location in patent: Paragraph 0346; 0348
[3] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00202
[4] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00160 |
| | 5-Bromo-4-chloro-2,6-dimethylpyrimidine Preparation Products And Raw materials |
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