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ISOCORYDINE HYDROCHLORIDE

ISOCORYDINE HYDROCHLORIDE Suppliers list
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:(+)-Isocorynoline
CAS:475-67-2
Purity:HPLC>=98% Package:20mg
Company Name: Chengdu Greenpure Biopharma CO.,Ltd
Tel: 18283602253; +8618283602253
Email: jancyzheng@gcgreenpure.com
Products Intro: Product Name:Isocorydine
CAS:475-67-2
Purity:98% Package:5mg
Company Name: Chengdu GLP biotechnology Co Ltd
Tel: 028-87075086 13350802083
Email: scglp@glp-china.com
Products Intro: Product Name:Isocorydine
CAS:475-67-2
Purity:98% Package:1g;5g;10g
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: +86-28-82633860; +8618080483897
Email: sales@biopurify.com
Products Intro: Product Name:Isocorydine
CAS:475-67-2
Purity:>95%,98%,99% Package:From mgs to grams,up to Kgs Remarks:Can be customized in bulk scale
Company Name: Shanghai Standard Technology Co., Ltd.
Tel: 18502101150
Email: ft-sales@nature-standard.com
Products Intro: Product Name:Isocorydine
CAS:475-67-2
Purity:>=98%(HPLC) Package:20mg;USD

ISOCORYDINE HYDROCHLORIDE manufacturers

  • Isocorydine
  • Isocorydine pictures
  • $47.00
  • 2026-07-15
  • CAS:475-67-2
  • Purity: 99.95%
  • Supply Ability: 10g
  • Isocorydine
  • Isocorydine pictures
  • 2023-02-24
  • CAS:475-67-2
  • Min. Order: 20mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 100 g
ISOCORYDINE HYDROCHLORIDE Basic information
Product Name:ISOCORYDINE HYDROCHLORIDE
Synonyms:LUTEANINE HYDROCHLORIDE;1,2,10-trimethoxy-6a-alpha-aporphin-11-o;4h-dibenzo(de,g)quinolin-11-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methy;artabotrin;d-isocorydine;l-(+)-isocorydine;luteanine(aporphine);D-ISOCORYDINE HYDROCHLORIDE
CAS:475-67-2
MF:C20H23NO4
MW:341.4
EINECS:
Product Categories:Inhibitors;Miscellaneous Natural Products;Alkaloids
Mol File:475-67-2.mol
ISOCORYDINE HYDROCHLORIDE Structure
ISOCORYDINE HYDROCHLORIDE Chemical Properties
Melting point 216-220 °C(lit.)
alpha D20 +195° (chloroform)
Boiling point 477.03°C (rough estimate)
density 1.2064 (rough estimate)
refractive index 1.5614 (estimate)
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form Cryst.
pka9.41±0.20(Predicted)
color White to off-white
InChIInChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)20(25-4)18-16(12)13(21)9-11-5-6-14(23-2)19(22)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1
InChIKeyQELDJEKNFOQJOY-ZDUSSCGKSA-N
SMILESN1(C)[C@]2([H])C3=C(C(OC)=C(OC)C=C3CC1)C1=C(O)C(OC)=CC=C1C2
Safety Information
WGK Germany 3
RTECS CE1057950
ToxicityLD50 intraperitoneal in mouse: 104mg/kg
MSDS Information
ISOCORYDINE HYDROCHLORIDE Usage And Synthesis
DescriptionIsocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.
Chemical PropertiesWhite powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Corydalis tuberosa DC., a plant of the Poppy family.
UsesIsocorydine is an alkaloid inhibitor of eukaryotic kinases.
Usessedative, cholinergic
UsesIsocorydine Hydrochloride is the hydrochloric acid of Isocorydine(I797000) which is an alkaloid inhibitor of eukaryotic kinases.
DefinitionChEBI: Isocorydine is an aporphine alkaloid.
in vivo

Isocorydine (intraperitoneal injection; 0.4 mg/kg; every 2 days for 2 weeks) retards the tumor growth, but the combined treatment of Doxorubicin (DOX) or ICD significantly inhibits tumor growth[1].

Animal Model:Female nude mice[1]
Dosage:0.4 mg/ml
Administration:Injected intraperitoneally every 2 days for 2 weeks
Result:Combined treatment of isocorydine and DOX showed a promising potential to eradicate HCC.
targetDopamine Receptor | P450 (e.g. CYP17)
ReferencesSee Isocorydine
ISOCORYDINE HYDROCHLORIDE Preparation Products And Raw materials
Preparation Products(+)-MENISPERINE IODIDE
Tag:ISOCORYDINE HYDROCHLORIDE(475-67-2) Related Product Information
(S)-1-(3,4-Dimethoxyphenyl)ethylamine 2-METHOXYBIPHENYL 1-BIPHENYL-2-YL-N-METHYLMETHYLAMINE 4-CHLORO-2-FLUOROBENZYLAMINE HYDROCHLORIDE ISOCORYDINE HYDROCHLORIDE (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol 2,6-Dimethylbenzylamine 3,4,5-TRIMETHYLPHENOL 2,2'-Biphenol 3-[(1S)-1-(Dimethylaminoethyl)]phenol (S)-7-METHOXY-1-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL (R)-4-(1-Aminoethyl)phenol (S)-hydroxybutanedioate salt SALSOLIDINE ISOCORYDINE HYDROCHLORIDE 1-(3,4-DIMETHOXY-PHENYL)-ETHYLAMINE 2,6-DIMETHYL-4-HYDROXYBENZYLAMINE (S)-o-Methyl-a-phenylethylamine 8-methyl-1,2,3,4-tetrahydroisoquinoline