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| | PROTRIPTYLINE HYDROCHLORIDE Basic information |
| | PROTRIPTYLINE HYDROCHLORIDE Chemical Properties |
| Melting point | 169-171° | | Fp | 9℃ | | storage temp. | 2-8°C | | solubility | H2O: soluble50mg/mL | | pka | 8.2(at 25℃) | | form | powder | | color | white to off-white | | Water Solubility | H2O: 50mg/mL | | Stability: | Hygroscopic | | InChI | InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H | | InChIKey | OGQDIIKRQRZXJH-UHFFFAOYSA-N | | SMILES | C1(CCCNC)C2C=CC=CC=2C=CC2C=CC=CC1=2.Cl |
| Hazard Codes | Xn,T,F | | Risk Statements | 20/21/22-36/37/38-39/23/24/25-23/24/25-11 | | Safety Statements | 26-36-45-36/37-16-7 | | RIDADR | 3249 | | WGK Germany | 3 | | RTECS | HP1400000 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 2921490002 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | | Toxicity | dog,LDLo,oral,400mg/kg (400mg/kg),"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 88, 1972. |
| | PROTRIPTYLINE HYDROCHLORIDE Usage And Synthesis |
| Uses | Monoamine reuptake inhibitor; tricyclic antidepressant. | | Brand name | Vivactil (Odyssey). | | General Description | Protriptyline hydrochloride, N-methyl-5H-dibenzo[a,d]-cycloheptene-5-propylamine hydrochloride, 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene hydrochloride(Vivactil), like the other compounds under consideration, isan effective antidepressant. The basis for its chemical namingcan be seen by consulting the naming and the structureof imipramine. Protriptyline is a structural isomer of nortriptyline.Inactivation can be expected to involve the relativelylocalized double bond. Because it is a monomethylcompound, its sedative potential is low. | | Biochem/physiol Actions | Norepinephrine uptake blocker. |
| | PROTRIPTYLINE HYDROCHLORIDE Preparation Products And Raw materials |
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