- (S)-Ketorolac
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- $74.00
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2026-05-11
- CAS:66635-92-5
- Purity:
- Supply Ability: 10g
- (S)-Ketorolac
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- $1.10
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2025-06-25
- CAS:66635-92-5
- Min. Order: 1g
- Purity: 99.0% min
- Supply Ability: 100 tons min
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| | (S)-Ketorolac Basic information |
| | (S)-Ketorolac Chemical Properties |
| Melting point | 160-167C | | Boiling point | 493.2±40.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Chloroform: Slightly; Ethanol: >1mg/ml; Methanol: Slightly | | form | A crystalline solid | | pka | 4.29±0.20(Predicted) | | color | White to off-white | | Optical Rotation | [α]/D -165 to -185°, c =0.5 in methanol | | InChI | 1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m0/s1 | | InChIKey | OZWKMVRBQXNZKK-NSHDSACASA-N | | SMILES | [n]21c(ccc2C(=O)c3ccccc3)[C@H](CC1)C(=O)O |
| WGK Germany | WGK 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | (S)-Ketorolac Usage And Synthesis |
| Description | (S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC50s = 0.1 and 2.7 μM for COX-1 and COX-2, respectively). (S)-Ketorolac is approximately twice as potent as the racemic mixture and 60 times more potent than (R)-ketorolac in a rat pain assay. (S)-Ketorolac is cleared from rat kidney and liver more quickly than (R)-ketorolac. Formulations containing ketorolac have been used to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation. | | Chemical Properties | Off-White Solid | | Uses | The R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory. | | Uses | (S)-Ketorolac is the S-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory. | | Definition | ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has S configuration. While (S)-ketorolac is a COX1 and COX2 inhibitor, both enantiomers exhibit analgesic effects. Racemic ketorolac, known s
mply as ketorolac, is used (mainly as the tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. | | References | [1] DR. DEAN A. HANDLEY PHD. Preclinical Enantioselective Pharmacology of (R)- and (S)- Ketorolac[J]. The Journal of Clinical Pharmacology, 2013, 38 2S: 25S-35S. DOI: 10.1002/j.1552-4604.1998.tb04414.x
[2] ANGEL GUSMAN. Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac[J]. Journal of Medicinal Chemistry, 1986, 29 4: 589-591. DOI: 10.1021/jm00154a027
[3] S K DUBEY R N S A Anand. Enantioselective Tissue Distribution of Ketorolac and its Enantiomers in Rats.[J]. Drug Research, 2015, 65 8: 428-431. DOI: 10.1055/s-0034-1389913
[4] DDS S M G, MPH Jaime S B D, MS Janet R R, et al. Peripheral prostanoid levels and nonsteroidal anti-inflammatory drug analgesia: Replicate clinical trials in a tissue injury model[J]. Clinical Pharmacology & Therapeutics, 2002, 72 2: 175-183. DOI: 10.1067/mcp.2002.126501 |
| | (S)-Ketorolac Preparation Products And Raw materials |
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