- (Z)-SMI-4a
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- $228.00
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2026-06-02
- CAS:438190-29-5
- Purity: 99.93%
- Supply Ability: 10g
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| | (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Basic information |
| | (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Chemical Properties |
| density | 1.530±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at +4°C | | solubility | DMSO: >10mg/mL | | form | powder | | pka | 7.38±0.20(Predicted) | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. | | InChI | 1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5- | | InChIKey | NGJLOFCOEOHFKQ-YVMONPNESA-N | | SMILES | FC(F)(F)c1cccc(\C=C2/SC(=O)NC2=O)c1 |
| Hazard Codes | Xi | | Risk Statements | 36-43 | | Safety Statements | 26-36/37 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Sens. 1 |
| | (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Usage And Synthesis |
| Description | SMI-4a (438190-29-5) is a selective, ATP-competitive inhibitor of the Pim protein kinases (IC50 = 24 and 100 nM for Pim-1 and Pim-2 respectively). Selective over a panel of ~50 other kinases.1Induces cell cycle arrest in leukemia and prostate cancer cells.2Blocks the growth of a wide range of myeloid and lymphoid cell lines with precursor T-cell lymphoblastic leukemia/lymphoma (pre-T-LBL/T-ALL) being highly sensitive.3SMI-4a is a useful tool for exploring the involvement of Pim in cellular signaling.4Cell permeable. | | Uses | SMI-4a is an aldose reductase inhibitor as well as a COX-2 inhibitor, a potential agent in the inhibition and treatment of cancer and cancer cell lines. | | IC 50 | PIM1: 24 μM (IC50); PIM1: 0.6 μM (Ki); PIM2: 100 μM (IC50) | | References | [1] ZUPING XIA. Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases[J]. Journal of Medicinal Chemistry, 2008, 52 1: 74-86. DOI:10.1021/jm800937p
[2] ZANNA BEHARRY. Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells.[J]. Molecular Cancer Therapeutics, 2009, 8 6: 1473-1483. DOI:10.1158/1535-7163.mct-08-1037
[3] YING-WEI LIN. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.[J]. Blood, 2010, 115 4: 824-833. DOI:10.1182/blood-2009-07-233445
[4] FENGXUE ZHANG. PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells.[J]. Cancer Biology & Therapy, 2009, 8 9: 846-853. DOI:10.4161/cbt.8.9.8210 |
| | (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Preparation Products And Raw materials |
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