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| | 5-(3,5-difluorobenzyl)-1H-indazol-3-amine Basic information |
| Product Name: | 5-(3,5-difluorobenzyl)-1H-indazol-3-amine | | Synonyms: | 5-(3,5-difluorobenzyl)-1H-indazol-3-amine;3-Amino-5-(3,5-difluorobenzyl)-1H-indazole;5-(3,5-difluoro-benzyl)-1H-indazol-3-ylamine;5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-amine;1H-Indazol-3-amine, 5-[(3,5-difluorophenyl)methyl]-;5-(3,5- difluorobenzyl)-1 h- azole-3-amine;(3,5-difluorobenzyl)-1H-indazol-3-amine;5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-amine - [D81383] | | CAS: | 1108745-30-7 | | MF: | C14H11F2N3 | | MW: | 259.25 | | EINECS: | | | Product Categories: | | | Mol File: | 1108745-30-7.mol |  |
| | 5-(3,5-difluorobenzyl)-1H-indazol-3-amine Chemical Properties |
| Boiling point | 450.7±40.0 °C(Predicted) | | density | 1.399±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 14.82±0.40(Predicted) | | Appearance | White to off-white Solid | | InChI | InChI=1S/C14H11F2N3/c15-10-4-9(5-11(16)7-10)3-8-1-2-13-12(6-8)14(17)19-18-13/h1-2,4-7H,3H2,(H3,17,18,19) | | InChIKey | CZQCRNRCCQSJHD-UHFFFAOYSA-N | | SMILES | N1C2=C(C=C(CC3=CC(F)=CC(F)=C3)C=C2)C(N)=N1 |
| | 5-(3,5-difluorobenzyl)-1H-indazol-3-amine Usage And Synthesis |
| Uses | 5-(3,5-difluorobenzyl)-1H-indazol-3-amine is an intermediates of Entrectinib(RXDX-101). Entrectinib (RXDX-101, NMS-E628) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces autophagy. |
| | 5-(3,5-difluorobenzyl)-1H-indazol-3-amine Preparation Products And Raw materials |
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