鹽酸甲哌卡因
| 中文名稱 | 鹽酸甲哌卡因 |
|---|---|
| 中文同義詞 | N-(2,6-二甲基苯基)-1-甲基-2-哌啶甲酰胺鹽酸鹽;鹽酸甲哌卡因;鹽酸卡波卡因;甲哌卡因鹽酸鹽;鹽酸甲哌卡因(堿基);MEPIVACAINE HCL 鹽酸甲哌卡因;鹽酸甲哌卡因,鹽酸卡波卡因;鹽酸甲哌卡因?, BR |
| 英文名稱 | Mepivacaine hydrochloride |
| 英文同義詞 | Mepivacaine Hydrochloride (200 mg);Ropivacaine base Mepivacaine HCL;(1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride;1-methyl-2’,6’-pipecoloxylididehydrochloride;Mepivacaine HCl USP;2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride;2',6'-Pipecoloxylidide, 1-methyl-, monohydrochloride (6CI, 8CI);2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (9CI) |
| CAS號 | 1722-62-9 |
| 分子式 | C15H22N2O.ClH |
| 分子量 | 282.81 |
| EINECS號 | 217-023-9 |
| 相關(guān)類別 | 醫(yī)藥原料;局部麻醉系列;麻醉類;小分子抑制劑;原料藥;對照品-雜質(zhì)對照品;麻醉藥及其輔助藥物;Sodium channel;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Analgesic series;API;藥物雜質(zhì)及中間體;醫(yī)藥原料藥;標(biāo)準(zhǔn)品 |
| Mol文件 | 1722-62-9.mol |
| 結(jié)構(gòu)式 |  |
鹽酸甲哌卡因 性質(zhì)
| 熔點 | 255-257°C (dec.) |
|---|---|
| 儲存條件 | 2-8°C |
| 溶解度 | 在水中的溶解度為20mg/mL，澄清 |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
| 水溶解性 | H2O: 20mg/mL, clear |
| InChI | InChI=1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H |
| InChIKey | RETIMRUQNCDCQB-UHFFFAOYSA-N |
| SMILES | C1(=C(C)C=CC=C1C)NC(=O)C1CCCCN1C.Cl |
| CAS 數(shù)據(jù)庫 | 1722-62-9(CAS DataBase Reference) |
| EPA化學(xué)物質(zhì)信息 | 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (1722-62-9) |
Mepivacaine 是一種叔胺，用作局部麻醉劑。
對馬的測試表明，與根據(jù)以前解剖的，乳膠注射后得到的假定相比，mepivacaine在相鄰關(guān)節(jié)結(jié)構(gòu)間具有更大的擴撒，與關(guān)節(jié)造影研究形成對比。經(jīng)歷膝關(guān)節(jié)鏡檢查患者中，與神經(jīng)刺激相比較，超聲處理使1.5% mepivacaine阻斷坐骨神經(jīng)所需的最低有效麻醉劑體積(MEAV50)減少37%。在犬齒和前臼齒中，lidocaine制劑與腎上腺素相比，3%mepivacaine的使用使麻醉時間間隔更短。
Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.
Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).
Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.
類別
有毒物質(zhì)毒性分級
中毒急性毒性
腹腔-小鼠 LD50: 117 毫克/公斤; 靜脈-小鼠 LD50: 35 毫克/公斤可燃性危險特性
熱分解排出有毒氮氧化物煙霧儲運特性
庫房低溫通風(fēng)干燥滅火劑
水, 二氧化碳, 泡沫, 干粉