|
|
| | 4-Amino-7H-pyrrolo[2,3-d]pyrimidine Basic information | | Application |
| | 4-Amino-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties |
| Melting point | 257-262℃ | | Boiling point | 318.3±45.0 °C(Predicted) | | density | 1.61±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 13.38±0.20(Predicted) | | form | Solid | | color | White to pale brown | | Sensitive | Moisture & Light Sensitive | | InChI | InChI=1S/C6H6N4/c7-5-4-1-2-8-6(4)10-3-9-5/h1-3H,(H3,7,8,9,10) | | InChIKey | PEHVGBZKEYRQSX-UHFFFAOYSA-N | | SMILES | C1=NC(N)=C2C=CNC2=N1 | | CAS DataBase Reference | 1500-85-2(CAS DataBase Reference) |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1/PG 1 | | WGK Germany | 2 | | RTECS | UY8850000 | | HazardClass | IRRITANT | | PackingGroup | Ⅲ | | HS Code | 2933599590 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral | | Toxicity | mouse,LD50,intraperitoneal,300mg/kg (300mg/kg),Gann. Japanese Journal of Cancer Research. Vol. 56, Pg. 219, 1965. |
| | 4-Amino-7H-pyrrolo[2,3-d]pyrimidine Usage And Synthesis |
| Application | 6-Amino-7-azapurine is a purine biological intermediate that can be used as a chemical raw material and pharmaceutical intermediate. | | Synthesis | A mixture of 5-ethynylpyrimidine-4,6-diamine (300mg, 2.24mmol), Cs2CO3 (1.46g, 4.47mmol) and DMSO (4.00ml) in a 10.00ml microwave tube was irradiated at 100W and 180°C for 15minutes. After this time, the reaction mixture was cooled to room temperature and poured into a separating funnel containing 100ml water and 100ml ethyl acetate. The aqueous layer was extracted with EtOAc (2×100ml). The combined organic extracts were dried with MgSO4 and filtered through celite, and excess solvent was removed in vacuo. Purification by column chromatography (80% EtOAc/hexane – 10% MeOH/CH2Cl2) gave 7H-pyrrolo[2,3-d]pyrimidin-4-amine (4-Amino-7H-pyrrolo[2,3-d]pyrimidine) (0.15g, 50%) as an off-white solid[1].
| | References | [1] Dr. Tswene D. Seanego. “7H-Pyrrolo[2,3-d]pyrimidine-4-amines as Potential Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinases.” ChemMedChem 17 22 (2022). |
| | 4-Amino-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials |
|