殼梭孢(菌)素
| 中文名稱 | 殼梭孢(菌)素 |
|---|---|
| 中文同義詞 | 殼梭孢(菌)素;殼梭孢菌素 來源于扁桃殼梭菌;FUSICOCCIN,真菌化膿毒素;化合物 FUSICOCCIN;FUSICOCCIN,H+-ATPASE活化劑 |
| 英文名稱 | FUSICOCCIN |
| 英文同義詞 | FUSICOCCIN;fusicoccin from fusicoccum amygdali;3-[2-(Acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethylcyclopenta[a,d]-dicylo coten-4-yl-6;.alpha.-D-Glucopyranoside, 3-[2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6A,7,8,9,10A-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10A-dimethyldicyclopenta[A,D]cycloocten-4-yl 6-o-(1,1-dimethyl-2-propenyl)-, 3-acetate, [1S-[1.alpha.,3(R*),4.alpha.,5.beta.,6.beta.,6A.alpha.,9.beta.,10A.beta.]]-;Fucicoccin;Nsc113500;Fusicoccin-A (Fusicoccin;α-D-Glucopyranoside, (1S,4R,5R,6R,6aS,9S,10aR)-3-[(1S)-2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethyldicyclopenta[a,d]cycloocten-4-yl 6-O-(1,1-dimethyl-2-propen-1-yl)-, 3-acetate |
| CAS號 | 20108-30-9 |
| 分子式 | C36H56O12 |
| 分子量 | 680.82 |
| EINECS號 | |
| 相關(guān)類別 | Carbohydrates;Carbohydrates A to;Carbohydrates D-FBiochemicals and Reagents;Monosaccharide |
| Mol文件 | 20108-30-9.mol |
| 結(jié)構(gòu)式 |  |
殼梭孢(菌)素 性質(zhì)
| 儲存條件 | −20°C |
|---|---|
| 溶解度 | 可溶于DMSO |
| 形態(tài) | 白色固體。 |
| 顏色 | 白色至米白色 |
| 生物來源 | plant (Fusicoccum amygdali) |
| InChIKey | KXTYBXCEQOANSX-QFEZKATASA-N |
| SMILES | COCC1CCC2C(C)C(O)C(OC3OC(COC(C)(C)C=C)C(O)C(OC(C)=O)C3O)C4=C(CC(O)C4(C)C=C12)C(C)COC(C)=O |
Fusicoccin (Fusicoccin A)，一種真菌化膿毒素，14-3-3 蛋白相互作用的穩(wěn)定劑。Fusicoccin 使 H+-ATPase/14-3-3 復(fù)合物在植物中穩(wěn)定，保持酶的激活狀態(tài)。Fusicoccin 還穩(wěn)定 14-3-3 蛋白與含有 C-末端 14-3-3 識別基序的結(jié)合伙伴的相互作用，如 ERα、GPIbα、TASK3、CTFR 和 p53。Fusicoccin 誘導(dǎo)一些癌細(xì)胞調(diào)亡，并具有抗癌活性。
Fusicoccin (Fusicoccin A) stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth (EC
50
=29 mM).
Fusicoccin A activates the plasma membrane H
+
-ATPase by stabilizing its binding to 14-3-3 proteins, which results in water loss and the wilting of infected plants. Fusicoccin A decreases the proliferation and migration of human GBM cell lines in vitro, including several cell lines that exhibit varying degrees of resistance to pro-apoptotic stimuli. The IC
50
growth inhibitory concentration of fusicoccin A is 92 μM in the U373-MG cells and 83 μM in the Hs683 glioma cells.
安全信息
| WGK Germany | 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 提供商 | 語言 |
|---|---|
|
英文
|
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-122815 | 殼梭孢(菌)素 Fusicoccin | 20108-30-9 | 1mg | 9600元 |