1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
生物活性靶點(diǎn)體內(nèi)研究 用途與合成方法 MSDS 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride價(jià)格(試劑級) 上下游產(chǎn)品信息
| 中文名稱 | 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride |
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| 中文同義詞 | 鹽酸左卡巴司丁;3-(3,4-二羥基苯基)-L-丙氨酸;3-羥基酪氨酸;L-Β-(3,4-二羥基苯基)初油氨基酸;L-Β-3,4-二羥基苯丙氨酸;左卡巴斯汀鹽酸鹽;左卡巴斯汀,用于系統(tǒng)適應(yīng)性1 EP標(biāo)準(zhǔn)品;鹽酸左卡巴斯汀 EP標(biāo)準(zhǔn)品 |
| 英文名稱 | 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride |
| 英文同義詞 | 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride;R50547;LIVOSTIN;[3s-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid;4-Piperidinecarboxylic acid, 1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, [3S-[1(cis),3a,4b]]-;4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, (3S,4R)- (9CI);Levophta, Levostin, R50547, [3S-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid;LEVOPHTA |
| CAS號 | 79547-78-7 |
| 分子式 | C26H30ClFN2O2 |
| 分子量 | 456.99 |
| EINECS號 | 209-062-5 |
| 相關(guān)類別 | 醫(yī)藥原料;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 79547-78-7.mol |
| 結(jié)構(gòu)式 |  |
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 性質(zhì)
| 儲存條件 | 2-8°C |
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| 溶解度 | DMSO：~10 mg/mL |
| 形態(tài) | 固體 |
| 顏色 | 白色 |
| 主要應(yīng)用 | 藥物（小分子） |
| InChIKey | OICFWWJHIMKBCD-VALQNVSPSA-N |
| SMILES | Cl[H].C[C@@H]1CN(CC[C@]1(C(O)=O)c2ccccc2)[C@@H]3CC[C@@](CC3)(C#N)c4ccc(F)cc4 |
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 用途與合成方法
Levocabastine hydrochloride (R 50547) 是一種具有抗過敏活性的長效、高效、選擇性組胺 H1 受體拮抗劑。Levocabastine hydrochloride 也是一種選擇性、高親和力的神經(jīng)降壓素受體亞型2 (NTR2) 拮抗劑，對 mNTR2 的 Ki 值為 17 nM。
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H 1 Receptor
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NTR2 17 nM (Ki) |
Levocabastine (0.25 mg/kg; i.p.; twice a day for five successive days; guinea-pigs) inhibits the virus-induced airway hyperresponsiveness, suppresses the influx of broncho-alveolar cells and increase in albumin content, and corrects the reduced chemiluminescence production by broncho-alveolar cells in response to zymosan.
In mice that receivedβ-LT, Levocabastine (0.05 mg/kg; i.p.) blocks the anxiolytic effect of β-LT and the number of head-dips decreased.
安全信息
| 提供商 | 語言 |
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英文
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| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-14277A | 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Levocabastine hydrochloride | 79547-78-7 | 1 mg | 1000元 |
| 2026/06/05 | HY-14277A | 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Levocabastine hydrochloride | 79547-78-7 | 5mg | 2700元 |