ARL 67156
| 中文名稱 | ARL 67156 |
|---|---|
| 中文同義詞 | 化合物 T14320;化合物 ARL67156 TRISODIUM SALT;ARL67156三鈉鹽 |
| 英文名稱 | ARL 67156 |
| 英文同義詞 | ARL67156 trisodium salt,ARL-67156 trisodium salt;[dibromo-[[[(2R,3S,4S,5R)-5-[6-(diethylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl]methyl]-hydroxyphosphinate |
| CAS號(hào) | 1021868-83-6 |
| 分子式 | C15H25Br2N5NaO12P3 |
| 分子量 | 743.11 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 1021868-83-6.mol |
| 結(jié)構(gòu)式 |  |
ARL 67156 性質(zhì)
| 儲(chǔ)存條件 | Desiccate at -20°C |
|---|---|
| 溶解度 | <15.78mg/ml，在水中 |
| 形態(tài) | 固體 |
| 顏色 | 白色 |
| 水溶解性 | Soluble to 20 mM in water |
ARL67156 trisodium salt 是一種 ecto-ATPase 抑制劑。ARL67156 trisodium salt 是弱的競(jìng)爭(zhēng)性 NTPDase1 (CD39)，NTPDase3 和 NPP1 抑制劑，Ki 分別為 11，18 和 12 μM。ARL67156 trisodium salt 可預(yù)防體內(nèi)主動(dòng)脈瓣鈣化。
Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)
ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes.
Pre-treatment of mice with ARL67156 (2?mg/kg, i.p.), a selective inhibitor of CD39 (CD39i), completely prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP; 100?mg/kg).
| Animal Model: | C57BL/6 mice |
| Dosage: | 2?mg/kg |
| Administration: | Pre-treated (i.p.) 1 ?h before administration of FBP (100?mg/kg) |
| Result: | Completely prevented the increase of serum adenosine concentration induced by FBP. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-103265 | ARL 67156 ARL67156 trisodium | 1021868-83-6 | 1 mg | 1800元 |
| 2026/06/05 | HY-103265 | ARL 67156 ARL67156 trisodium | 1021868-83-6 | 5 mg | 5400元 |