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葫蘆素 I

葫蘆素 I

中文名稱葫蘆素 I
中文同義詞葫蘆素 I;葫蘆素;葫蘆素I(甄準(zhǔn)不供應(yīng));CUCURBITACIN I 葫蘆素I;葫蘆素I 117793;葫蘆素 I,10 MM DMSO 溶液;CUCURBITACIN I 葫蘆素I/ELATERICIN B(NSC-521777) |CAS 2222-07-3;Cucurbitacin I試劑
英文名稱CUCURBITACIN I
英文同義詞ELATERICIN B;ELATERIN B;Cucurbitacin I hydrate;Elatericin B, JSI-124, NSC 521777, 2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione;(9β,10α,23E)-2,16α,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione;Ibamarin;2,16a,20,25-Tetrahydroxy-9b-methyl-10a-19-norlanosta-1,5,23(E)-triene-3,11,22-trione;2,16α,20,25-tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
CAS號(hào)2222-07-3
分子式C30H42O7
分子量514.65
EINECS號(hào)218-736-8
相關(guān)類別植物提取物;中藥對(duì)照品;對(duì)照品;小分子;Inhibitor;Herb extract;API;Tri-Terpenoids
Mol文件2222-07-3.mol
結(jié)構(gòu)式葫蘆素 I 結(jié)構(gòu)式

葫蘆素 I 性質(zhì)

熔點(diǎn)148-150°C
沸點(diǎn)698.3±55.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C
溶解度DMSO 中≥22.45 mg/mL;不溶于乙醇;超聲檢測(cè)水中≥51.2 mg/mL
酸度系數(shù)(pKa)8.51±0.70(Predicted)
形態(tài)固體
顏色白色至類白色
InChIKeyNISPVUDLMHQFRQ-KUIOOTTBNA-N
SMILES[C@@]12(C)CC(O)C(C(O)(C)C(=O)/C=C/C(O)(C)C)[C@@]1(C)CC(=O)[C@]1(C)C3C=C(C(=O)C(C)(C)C3=CC[C@@]21[H])O |&1:0,17,22,35,r|
LogP2.330 (est)

葫蘆素 I 用途與合成方法

Cucurbitacin I 是 JAK2/STAT3 的天然選擇性抑制劑,并具有有效的抗腫瘤活性。

JAK2

STAT3

Exposure of the COLO205 cells to Cucurbitacin I significantly decreases cell viability. The anticancer activity of Cucurbitacin I is accomplished by downregulating p-STAT3 and MMP-9 expression. PE-induced cell enlargement and upregulation of ANF and β-MHC are significantly suppressed by pretreatment of the cardiomyocytes with Cucurbitacin I. Notably, Cucurbitacin I also impaires connective tissue growth factor (CTGF) and MAPK signaling, pro-hypertrophic factors, as well as TGF-β/Smad signaling, the important contributing factors to fibrosis. Incubation of the Seax cell line with the Jak/Stat3 inhibitor Cucurbitacin I result in a time- and concentration-dependent decrease of P-Stat3 and Stat3. In freshly isolated Sz cells (n=3), Cucurbitacin I induces a concentration-dependent decrease in Stat3 expression whereas P-Stat3 is undetectable. Finally, incubation of freshly isolated Sz cells (n=4) with 30 μM Cucurbitacin I for 6 hours induces apoptosis in the large majority (73-91%) of tumor cells.

No major side effects are noted throughout the study. It is shown that average tumor volumes at the end of the study are as follows: control, 616 mm 3 (±130); CQ, 580 mm 3 (±107); Cucurbitacin I, 346mm 3 (±79); and combination, 220mm 3 (±62). The differences in tumor volume between the Cucurbitacin I and control, combination and control, and combination and Cucurbitacin I arms are significant. Furthermore, combination-treated tumors exhibit a significantly lower average tumor weight at study termination than the control. Moreover, there was no effect on the body weights of mice.

安全信息

危險(xiǎn)品標(biāo)志Xi,T+
危險(xiǎn)類別碼25-28
安全說明1-22-45-36/37-28
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 1
WGK Germany3
RTECS號(hào)RC6200000
存儲(chǔ)類別6.1A - 可燃,急性毒性物質(zhì)(類別1和類別2)
劇毒的危險(xiǎn)物質(zhì)
危險(xiǎn)性類別急性毒性 類別1 經(jīng)口
毒性LD50 oral in mouse: 5mg/kg

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-N1405葫蘆素 I
Cucurbitacin I
2222-07-31mg950元
2026/06/05HY-N1405葫蘆素 I
Cucurbitacin I
2222-07-35mg3000元

葫蘆素 I 上下游產(chǎn)品信息

"葫蘆素 I"相關(guān)產(chǎn)品信息
雪膽素乙 2-烯丙基環(huán)己酮 1,2-環(huán)己二酮 薄荷酮 2-叔丁基丙烷-1,3-二醇 葫蘆素I 2,6,8-三甲基-4-壬酮 2,6,10-三甲基-9-烯-十一醛 植酮 2,6-二甲基-5-庚烯醛 2-羥基己二醛 葫蘆素C 葫蘆素IIA 葫蘆素D 葫蘆素F-25-乙酸酯 葫蘆素F 葫蘆素E 葫蘆素D
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