FEN1 Inhibitor C2
| 中文名稱 | FEN1 Inhibitor C2 |
|---|---|
| 中文同義詞 | 1-(環(huán)丙基甲基)-3-羥基喹唑啉-2,4(1H,3H)-二酮;化合物FEN1 INHIBITOR C2;化合物FEN1 INHIBITOR C2,10 MM DMSO 溶液;FEN1-IN-4 試劑;FEN1-IN-4 ,S3397;FEN1-IN-4 試劑;FEN1-IN-4【CAS:1995893-58-7】【規(guī)格:5mg】【純度:99%】;FEN1-IN-4【CAS：1995893-58-7】【規(guī)格：5mg】【純度：99%】 |
| 英文名稱 | FEN1 Inhibitor C2 |
| 英文同義詞 | FEN1 Inhibitor C2;FEN1-IN-4;2,4(1H,3H)-Quinazolinedione, 1-(cyclopropylmethyl)-3-hydroxy-;1-(Cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione;flap,colorectal,Inhibitor,endonuclease,FEN1IN4,cells,colon,cancer,inhibit,FEN-1-IN-4,glioblastoma,FEN1 IN 4,human,hFEN1;FEN1-IN-4, 10 mM in DMSO;FEN1-IN-4 ，S3397 |
| CAS號 | 1995893-58-7 |
| 分子式 | C12H12N2O3 |
| 分子量 | 232.24 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 1995893-58-7.mol |
| 結構式 |  |
FEN1 Inhibitor C2 性質
| 儲存條件 | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| 溶解度 | 二甲基亞砜：125 mg/mL（538.24 mM） |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至黃色 |
FEN1-IN-4 (Compound 2) 是一種人類皮瓣內切核酸酶-1 (hFEN1) 抑制劑。
hFEN1
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a , both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.
安全信息
| 更新日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/03/03 | S3397 | FEN1 Inhibitor C2 FEN1-IN-4 | 1995893-58-7 | 5mg | 1547.91元 |
| 2026/03/03 | S3397 | FEN1-IN-4 | 1995893-58-7 | 10mM (1mL in DMSO) | 1793.61元 |