| Company Name: |
Hunan Hui Bai Shi Biotechnology Co., Ltd.
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| Tel: |
0731-85526065 13308475853 |
| Email: |
ivy@hnhbsj.com |
| Products Intro: |
Product Name:Haptoglobin from pooled human plasma
CAS:9087-69-8
Purity:BR，95% Package:5g;25g
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| Company Name: |
Shanghai Ruji Biology Technology Co., Ltd.
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| Tel: |
+86-21-65211385-8001 36031160 |
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sales@shruji.com |
| Products Intro: |
Product Name:Haptoglobin froM pooled huMan plasMa
CAS:9087-69-8
Purity:BR,95% Package:1680RMB/1Mg Remarks:20℃
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| Company Name: |
Nanjing Dulai Biotechnology Co., Ltd.
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| Tel: |
025-84699383-8003;025-846993838003-8003 18013301593;18013301590 |
| Email: |
njduly@126.com |
| Products Intro: |
Product Name:Haptoglobin from pooled human plasma
CAS:9087-69-8
Purity:95% (SDS-PAGE) Package:1mg
|
| Company Name: |
Shanghai BeiZhuo Biotech Co., Ltd.
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| Tel: |
021-61119791,13386096464 |
| Email: |
bzswkf@foxmail.com |
| Products Intro: |
Product Name:haptoglobin froM huMan plasMa
CAS:9087-69-8
Purity:HPLC>=98% Package:On Request
|
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| | HAPTOGLOBIN, HUMAN Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: 10 mg/mL, clear to faintly turbid, colorless to almost colorless | | form | powder | | color | off-white | | biological source | human plasma (pooled) | | Water Solubility | water: 1mg/mL |
| Hazard Codes | B | | WGK Germany | 3 | | RTECS | MG8575500 | | HS Code | 3504009000 | | Storage Class | 11 - Combustible Solids |
| | HAPTOGLOBIN, HUMAN Usage And Synthesis |
| Uses | Haptoglobin was used to study induction of the acrosome reaction in sperm. Exposure to low temperature increases their rate of fusion with zona-free hamster oocytes. | | General Description | Haptoglobin is an α2-globulin found in normal plasma at a concentration of 82-236 mg/dl and accounts for 0.4-2.6% of the total plasma proteins.The monomeric form of this acute phase plasma protein is composed of four polypeptide chains: two α chains and two β chains. | | Biochem/physiol Actions | Functions by binding to plasma hemoglobin (from hemolysis). The complex is removed from the circulation, by binding to CD163 receptors on macrophages, to salvage iron and prevent oxidative damage. | | Description | Haptoglobin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing?fusion protein with His tag and having a total Mw of 33 kDa (4 kDa His-tag). | | Source | Escherichia Coli | | Background | Haptoglobin is a glycoprotein which is synthesized in the liver and circulates in the blood. Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, and kidney. It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury, and iron loss following hemolysis. The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system (generally the spleen). As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body, haptoglobin levels are reduced in hemolytic anaemias. In the course of binding hemoglobin, haptoglobin sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis.
Haptoglobin consists of two A- and two B-chains, connected by disulfide bonds. Three major haptoglobin phenotypes are known to exist (Hp 1-1, Hp 2-1, and Hp 2-2). Hp 1-1 is biologically the most effective in binding free hemoglobin and suppressing inflammatory responses associated with free hemoglobin. Hp 2-2 is biologically the least active, and Hp 2-1 is moderately active. Haptoglobin’s molecular mass ranges from 8-200 kDa.
Reduced levels can be seen in haemolysis and impaired liver function. High levels are a marker for acute or chronic inflammation. Ahaptoglobinemia or hypohaptoglobinemia are caused by mutations in the haptoglobin gene and/or its regulatory regions. Haptoglobin is also linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. |
| | HAPTOGLOBIN, HUMAN Preparation Products And Raw materials |
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