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| | Tomatidine hydrochloride Basic information |
| | Tomatidine hydrochloride Chemical Properties |
| Melting point | 281-284°C (dec.) | | storage temp. | 2-8°C | | solubility | Methanol (Slightly) | | form | Off-white solid | | color | White to Off-White | | BRN | 3920740 | | InChIKey | SXXHVPYRDFJKPG-GSTSPNSONA-N | | SMILES | Cl[H].[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3([H])C[C@]5([H])O[C@]6(CC[C@H](C)CN6)[C@@H](C)[C@]45[H])[C@@]1(C)CC[C@H](O)C2 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | Tomatidine hydrochloride Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid). | | Biological Activity | Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway. | | IC 50 | p65; JNK | | Mode of action | Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans. |
| | Tomatidine hydrochloride Preparation Products And Raw materials |
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