LtaS-IN-1
| 中文名稱 | LtaS-IN-1 |
|---|---|
| 中文同義詞 | 化合物 T11888;化合物L(fēng)TAS-IN-1;化合物L(fēng)TAS-IN-1,10 MM DMSO 溶液;2-氧代-2-((5-苯基-1,3,4-噁二唑-2-基)氨基)乙基 2-(萘并[2,1-b]呋喃-1-基)乙酸酯 |
| 英文名稱 | LtaS-IN-1 |
| 英文同義詞 | LtaS-IN-1;Naphtho[2,1-b]furan-1-acetic acid, 2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl ester;(5-phenyl-1,3,4-oxadiazol-2-yl)carbamoyl]methyl 2-{naphtho[2,1-b]furan-1-yl}acetate;2-oxo-2-((5-phenyl-1,3,4-oxadiazole-2-yl)amino-)ethyl 2-(naphtho[2,1-b]furo-1-yl)acetate;Bacterial,MDR,E. faecium,LtaSIN1,multidrug-resistant,inhibit,LtaS IN 1,anti-bacterial,Inhibitor;LtaS-IN-1, 10 mM in DMSO;2-Oxo-2-((5-phenyl-1,3,4-oxadiazol-2-yl)amino)ethyl 2-(naphtho[2,1-b]furo-1-yl)-acetate;2-Oxo-2-((5-phenyl-1,3,4-oxadiazol-2-yl)amino)ethyl 2-(naphtho[2,1-b]furan-1-yl)acetate |
| CAS號 | 877950-01-1 |
| 分子式 | C24H17N3O5 |
| 分子量 | 427.41 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 877950-01-1.mol |
| 結(jié)構(gòu)式 |  |
LtaS-IN-1 性質(zhì)
| 密度 | 1.400±0.06 g/cm3(Predicted) |
|---|---|
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 9.67±0.70(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至黃色 |
MIC: 0.5 μg/mL (strain E1630); 0.5 μg/mL (strain E1590)
LtaS-IN-1 (0-100 μM) inhibits strain E745 growth as a concentration-dependent manner. At the concentration 10 μM leads to an 60% reduction in the final OD600 for this strain. Meanwhile, LtaS-IN-1 does not affect E. faecium growth in control group. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with the MIC values of 0.5μg/mL. LtaS-IN-1 (20 μM) combines with either ampicillin (20 μg/mL), gentamicin (10 μg/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL+50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growth by 97-100%, while LtaS-IN-1 alone only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-135813 | LtaS-IN-1 | 877950-01-1 | 1 mg | 385元 |
| 2026/06/05 | HY-135813 | LtaS-IN-1 LtaS-IN-1 | 877950-01-1 | 5mg | 885元 |