D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-
生物活性靶點(diǎn)體內(nèi)研究 用途與合成方法 MSDS D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-價(jià)格(試劑級) 上下游產(chǎn)品信息
| 中文名稱 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- |
|---|---|
| 中文同義詞 | 化合物 T26745;化合物BAY 73-1449;化合物BAY 73-1449,10 MM DMSO 溶液 |
| 英文名稱 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- |
| 英文同義詞 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-;BAY 73-1449;vessel,portal,pressure,mesenteric,porto-systemic,inhibit,BAY 731449,blood,BAY 73 1449,prostacyclin,inflow,BAY 73-1449,splenic,Inhibitor,shunt,lower,Prostaglandin Receptor,outflow;BAY 73-1449, 10 mM in DMSO |
| CAS號 | 693790-96-4 |
| 分子式 | C26H23N3O3 |
| 分子量 | 425.48 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 693790-96-4.mol |
| 結(jié)構(gòu)式 | ![D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- 結(jié)構(gòu)式](CAS/20210111/GIF/693790-96-4.gif) |
D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- 性質(zhì)
| 沸點(diǎn) | 700.4±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.273±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 二甲基亞砜：250 mg/mL（587.57 mM） |
| 酸度系數(shù)(pKa) | 3.35±0.10(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
BAY 73-1449 是一種選擇性前列環(huán)素受體 (prostacyclin receptor, IP) 的拮抗劑，在人 HEL 細(xì)胞和大鼠 DRG 的 cAMP 分析中具有很高的效價(jià) (IC50 值小于 0.1 nM)。BAY 73-1449 可用于降血壓的研究。
|
IP Receptor <0.1 nM (IC 50 ) |
BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats.
BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats.
BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats.
| Animal Model: | Male Wistar rats (250-350 g) are ligated portal vein |
| Dosage: | 0.1, 1 mg/kg |
| Administration: | A single i.v. |
| Result: | Significantly reduced shunt flow without affecting mesenteric flow. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-118941 | BAY 73-1449 | 693790-96-4 | 1 mg | 700元 |
| 2026/06/05 | HY-118941 | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- BAY 73-1449 | 693790-96-4 | 5mg | 1475元 |