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TERT-BUTYL 4-BROMOBENZYLCARBAMATE

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Products Intro: Product Name:TERT-BUTYL 4-BROMOBENZYLCARBAMATE
CAS:68819-84-1
Purity:0.98 Package:5KG;1KG；500g，100g，50g
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Products Intro: Product Name:N-Boc-4-bromobenzylamine
CAS:68819-84-1
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Products Intro: Product Name:tert-Butyl 4-bromobenzylcarbamate
CAS:68819-84-1
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Products Intro: Product Name:TERT-BUTYL 4-BROMOBENZYLCARBAMATE
CAS:68819-84-1
Purity:99% Package:1KG;1USD
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Products Intro: Product Name:TERT-BUTYL 4-BROMOBENZYLCARBAMATE
CAS:68819-84-1
Purity:0.99 Package:5KG;1KG

TERT-BUTYL 4-BROMOBENZYLCARBAMATE manufacturers
TERT-BUTYL 4-BROMOBENZYLCARBAMATE Basic information
Product Name:TERT-BUTYL 4-BROMOBENZYLCARBAMATE
Synonyms:TERT-BUTYL 4-BROMOBENZYLCARBAMATE;Carbamic acid, (4-bromophenyl)methyl-, 1,1-dimethylethyl ester;(4-BROMO-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER;4-Bromo-N-BOC-benzylamine;N-(4-Bromobenzyl)carbamic acid tert-butyl ester;tert-Butyl N-(4-bromobenzyl)carbamate;Carbamic acid, N-[(4-bromophenyl)methyl]-, 1,1-dimethylethyl ester;tert-Butyl 4-bromobenzylcarbamate 98%
CAS:68819-84-1
MF:C12H16BrNO2
MW:286.16
EINECS:
Product Categories:amine|alkyl bromide| carboxylic ester
Mol File:68819-84-1.mol
TERT-BUTYL 4-BROMOBENZYLCARBAMATE Structure
TERT-BUTYL 4-BROMOBENZYLCARBAMATE Chemical Properties
Melting point 86-88℃
Boiling point 374.3±25.0 °C(Predicted)
density 1.319±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form solid
pka12.05±0.46(Predicted)
color Off-white
InChIInChI=1S/C12H16BrNO2/c1-12(2,3)16-11(15)14-8-9-4-6-10(13)7-5-9/h4-7H,8H2,1-3H3,(H,14,15)
InChIKeyDJNCXSGGAMADNN-UHFFFAOYSA-N
SMILESC(OC(C)(C)C)(=O)NCC1=CC=C(Br)C=C1
Safety Information
Hazard Codes Xn
Risk Statements 22
HS Code 2924297099
MSDS Information
TERT-BUTYL 4-BROMOBENZYLCARBAMATE Usage And Synthesis
SynthesisTert-Butyl 4-bromobenzylcarbamate is prepared by the reaction of di-tert-butyl dicarbonate and 4-bromobenzylamine hydrochloride. The specific synthesis steps are as follows:
To a stirred suspension of 4-bromo-benzylamine hydrochloride (968mg, 4.35mmol) and triethylamine (0.666ml, 4.79mmol) in chloroform (15ml) was added di-tert-butyldicarbonate (949mg, 4.35mmol). The resulting solution was stirred at ambient temperature for 2h and then diluted with DCM (40ml). The organic solution was washed sequentially with 10% aqueous citric acid (40ml) and brine (40ml). The organic phase was dried over anhydrous magnesium sulfate and the filtrate evaporated at reduced pressure to afford Tert-Butyl 4-bromobenzylcarbamate (1.23g, 99%). 1H NMR 7.48-7.43 (2H, m), 7.18 (2H, d, 8.4), 4.84 (1H, br s), 4.27 (2H, d, 5.7), 1.46 (9H, s).
TERT-BUTYL 4-BROMOBENZYLCARBAMATE synthesis
References[1] Patent: EP1056733, 2004, B1. Location in patent: Page 26
[2] Patent: WO2007/28083, 2007, A2. Location in patent: Page/Page column 84
[3] Patent: CN105622638, 2016, A. Location in patent: Paragraph 0312
[4] Tetrahedron, 2001, vol. 57, # 23, p. 4945 - 4954
[5] Chemistry - A European Journal, 2017, vol. 23, # 12, p. 2877 - 2883
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