| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:FIIN-4
CAS:2093088-81-2
Purity:99.96% Package:1mg/RMB 1380;5mg/RMB 3330;10mg/RMB 4670
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Products Intro: |
Product Name:FIIN-4
CAS:2093088-81-2
|
2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]- manufacturers
- FIIN-4
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- $197.00
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2026-04-21
- CAS:2093088-81-2
- Purity: 99.96%
- Supply Ability: 10g
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| | 2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]- Basic information |
| Product Name: | 2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]- | | Synonyms: | 2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-;N-(3-((3-(3,5-dimethoxyphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide;N-(3-{3-(3,5-Dimethoxy-phenyl)-7-[4-(4-methyl-piperazin-1-yl)-phenylamino]-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-1-ylmethyl} -phenyl)-acrylamide | | CAS: | 2093088-81-2 | | MF: | C35H38N8O4 | | MW: | 634.73 | | EINECS: | | | Product Categories: | | | Mol File: | 2093088-81-2.mol | ![2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]- Structure](CAS/20210305/GIF/2093088-81-2.gif) |
| | 2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]- Chemical Properties |
| density | 1.306±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 10mg/mL, clear | | pka | 13.54±0.70(Predicted) | | form | powder | | color | white to beige |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]- Usage And Synthesis |
| Description | FIIN-4 is a first-in-class covalent inhibitor of FGFR (Fibroblast Growth Factor Receptor) that inhibits metastatic breast cancer. Structurally, FIIN-4 is an regional isomer of FIIN-2 (Cat#406652). FIIN-4 effectively blocks 3D metastatic outgrowth as compared with currently available FGFR inhibitors. In vivo application of FIIN-4 potently inhibited the growth of metastatic, patient-derived breast cancer xenografts and murine-derived metastases growing within the pulmonary microenvironment. (Copied from Mol Cancer Ther. 2016 Sep;15(9):2096-106. ) | | Uses | FIIN-4 is a first-in-class, orally active and covalent FGFR inhibitor with IC50s of 2.6 nM, 2.6 nM, 5.6 nM, 9.2 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. FIIN-4 can inhibit metastatic tumor growth. | | References | [1] Wells S Brown, et al. Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer. Mol Cancer Ther. 2016 Sep;15(9):2096-106. DOI:10.1158/1535-7163.MCT-16-0136 |
| | 2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]- Preparation Products And Raw materials |
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