ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE manufacturers
|
| | ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE Basic information |
| Product Name: | ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE | | Synonyms: | 6-TRIFLUOROMETHYL-2-INDOLECARBOXYLIC ACID ETHYL ESTER;Ethyl 6-(trifluoroMethyl)-1H-indole-2-carboxylate;6-TrifuoroMethyl-2-indolecarboxylic acid ethyl ester;1H-Indole-2-carboxylicacid, 6-(trifluoromethyl)-, ethyl ester;-1H-indole-2-carboxylate;6-trifluoromethyl-indole-2-carboxylic acid ethyl ester | | CAS: | 327-21-9 | | MF: | C12H10NO2F3 | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | 327-21-9.mol |  |
| | ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | Appearance | Off-white to light yellow Solid |
| | ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE Usage And Synthesis |
| Synthesis | To a 1000 mL three-necked flask was added (E)-ethyl-2-(2-(3-(trifluoromethyl)phenyl)hydrazinyl)propionate (26 g, 94.8 mmol) synthesized in Step 1 and toluene. Subsequently, polyphosphoric acid (150 g) was slowly added to the reaction system, heated to reflux and maintained for 6 hours. After completion of the reaction, the reaction mixture was cooled to 50°C and the toluene layer was separated. The toluene layer was concentrated to dryness under reduced pressure. Toluene (50 mL) was added to the resulting solid, refluxed for 1 hour and cooled to room temperature. The recrystallized product was collected by filtration to afford ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate (1.25 g, 4.86 mmol, 5% yield). | | References | [1] Patent: KR101741956, 2017, B1. Location in patent: Paragraph 0411; 0415-0417 |
| | ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE Preparation Products And Raw materials |
|