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| | Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) Basic information |
| Product Name: | Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) | | Synonyms: | (R)-3-(Boc-aMino)-2-oxopiperidine;(R)-3-(Boc-aMino)-2-piperidone;N-[(3R)-2-Oxo-3-piperidinyl]carbamic acid 1,1-dimethylethyl ester;-tert-Butyl (2-oxopiperidin-3-yl);Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI);tert-Butyl (R)-2-oxopiperidin-3-ylcarbamate;(R)-tert-butyl 2-oxopiperidin-3-ylcarbamate;CarbaMic acid,N-[(3R)-2-oxo-3-piperidinyl]-, 1,1-diMethylethyl ester | | CAS: | 221874-51-7 | | MF: | C10H18N2O3 | | MW: | 214.26 | | EINECS: | | | Product Categories: | N-BOC | | Mol File: | 221874-51-7.mol | ![Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) Structure](CAS/GIF/221874-51-7.gif) |
| | Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties |
| Boiling point | 405.6±34.0 °C(Predicted) | | density | 1.11±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 11.05±0.20(Predicted) | | Appearance | White to off-white Solid |
| | Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) Usage And Synthesis |
| Synthesis | General procedure for the synthesis of (R)-tert-butyl(2-oxopiperidin-3-yl)carbamic acid from di-tert-butyl dicarbonate and (R)-3-aminopiperidin-2-one: (R)-3-aminopiperidin-2-one (1.00 g, 8.76 mmol) was dissolved in dichloromethane (15 mL), triethylamine (1.28 mL, 9.2 mmol) and di-tert-butyl dicarbonate were added. butyl dicarbonate (2.01 g, 9.2 mmol). The reaction mixture was stirred at room temperature for 12 hours and then concentrated under vacuum. The crude product was diluted with ether (50 mL) and filtered through a diatomaceous earth pad. The filtrate was evaporated to dryness and purified by silica gel column chromatography (50 g of silica gel, 100% ethyl acetate) to give 1.65 g of colorless foamy (R)-tert-butyl(2-oxopiperidin-3-yl)carbamic acid in 88% yield. | | References | [1] Patent: JP5667692, 2015, B2. Location in patent: Paragraph 0199-0201
[2] Tetrahedron Letters, 1999, vol. 40, # 5, p. 935 - 938
[3] Tetrahedron, 1999, vol. 55, # 18, p. 5793 - 5808 |
| | Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials |
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