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| | 2-AMINO-4-FLUOROPHENOL Chemical Properties |
| Melting point | 130-135 °C | | Boiling point | 252.9±25.0 °C(Predicted) | | density | 1.347±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 9.77±0.18(Predicted) | | color | Light yellow to Brown | | InChI | InChI=1S/C6H6FNO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H,8H2 | | InChIKey | ULDFRPKVIZMKJG-UHFFFAOYSA-N | | SMILES | C1(O)=CC=C(F)C=C1N | | CAS DataBase Reference | 399-97-3(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 20/21/22-36/37/38-22 | | Safety Statements | 26-36/37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29222990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-AMINO-4-FLUOROPHENOL Usage And Synthesis |
| Application | 2-Amino-4-fluorophenol has wide applications in drug synthesis, serving as a synthetic intermediate for certain drugs. Furthermore, it possesses antibacterial and anti-inflammatory properties, making it useful in treating some infectious and inflammatory diseases. | | Chemical Properties | White to brown solid | | Synthesis | The general procedure for the synthesis of 2-amino-4-fluorophenol from 2-nitro-4-fluorophenol was as follows: tin(II) chloride (12.1 g, 63.6 mmol) was added to a solution of 4-fluoro-2-nitrophenol (2.00 g, 12.7 mmol) in ethanol (45 mL). The reaction mixture was heated to 70 °C and maintained at this temperature for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into ice water (~200 mL). After the mixture was warmed to room temperature, the pH was adjusted with 2N NaOH aqueous solution to about 9. The reaction mixture was filtered and the filtrate was extracted with ethyl acetate (3×). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the organic phase was concentrated under reduced pressure. 1.21 g (75% yield) of 2-amino-4-fluorophenol was finally obtained.Results of LC-MS analysis: retention time (RT) = 4.48 min, [M + H]+ = 128.0. | | References | [1] Patent: EP1346982, 2003, A1
[2] Inorganic Chemistry, 2010, vol. 49, # 23, p. 11106 - 11117
[3] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 80
[4] Journal of Organic Chemistry, 1951, vol. 16, p. 1345,1348
[5] J. Gen. Chem. USSR (Engl. Transl.), 1975, vol. 45, p. 2372 - 2379 |
| | 2-AMINO-4-FLUOROPHENOL Preparation Products And Raw materials |
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