4-Morpholinecarbothioic acid, 2-(2-pyrazinylcarbonyl)hydrazide

4-Morpholinecarbothioic acid, 2-(2-pyrazinylcarbonyl)hydrazide Suppliers list
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Products Intro: Product Name:AF615
CAS:122510-61-6
Purity:AF615 Package:1g;5g;10g Remarks:98% HPLC
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
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Products Intro: Product Name:AF615
CAS:122510-61-6
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Products Intro: Product Name:AF615
CAS:122510-61-6
Purity:98% Package:1g
Company Name: cjbscvictory  
Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Products Intro: Product Name:AF615
CAS:122510-61-6
Purity:>=98% Package:5mg10mg20mg0mg100mg00mg1g2g等應(yīng)客戶需求包裝
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd  
Tel: 024-88590548 18698872706
Email: 757984502@qq.com
Products Intro: Product Name:AF615
CAS:122510-61-6
Purity:98% HPLC Package:1g;5g;10g
4-Morpholinecarbothioic acid, 2-(2-pyrazinylcarbonyl)hydrazide Basic information
Product Name:4-Morpholinecarbothioic acid, 2-(2-pyrazinylcarbonyl)hydrazide
Synonyms:4-Morpholinecarbothioic acid, 2-(2-pyrazinylcarbonyl)hydrazide;AF615;N'-(morpholine-4-carbothioyl)pyrazine-2-carbohydrazide
CAS:122510-61-6
MF:C10H13N5O2S
MW:267.31
EINECS:
Product Categories:
Mol File:122510-61-6.mol
4-Morpholinecarbothioic acid, 2-(2-pyrazinylcarbonyl)hydrazide Structure
4-Morpholinecarbothioic acid, 2-(2-pyrazinylcarbonyl)hydrazide Chemical Properties
Melting point 184-185 °C(Solv: methanol (67-56-1))
density 1.398±0.06 g/cm3(Predicted)
pka8.54±0.23(Predicted)
Safety Information
MSDS Information
4-Morpholinecarbothioic acid, 2-(2-pyrazinylcarbonyl)hydrazide Usage And Synthesis
UsesAF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex (IC50 = 0.313 μM). AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 μM in case of Geminin-tCDT1 interaction and a Ki = 0.75 μM in case of Geminin-miniCDT1 interaction[1].
References[1] Nikolaos Karantzelis, et al. Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells. Front Pharmacol. 2022 Apr 25;13:860682.
4-Morpholinecarbothioic acid, 2-(2-pyrazinylcarbonyl)hydrazide Preparation Products And Raw materials
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