LT-540-717 manufacturers
- LT-540-717
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2026-05-11
- CAS:2143089-35-2
- Purity:
- Supply Ability: 10g
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| | LT-540-717 Basic information |
| Product Name: | LT-540-717 | | Synonyms: | LT-540-717;1H-Pyrazole-3-carboxamide, 4-[(6-phenoxy-4-pyrimidinyl)amino]-N-[4-(1-piperazinyl)phenyl]- | | CAS: | 2143089-35-2 | | MF: | C24H24N8O2 | | MW: | 456.5 | | EINECS: | | | Product Categories: | | | Mol File: | 2143089-35-2.mol |  |
| | LT-540-717 Chemical Properties |
| Boiling point | 670.766±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.378±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 11.487±0.70(predicted) |
| | LT-540-717 Usage And Synthesis |
| Uses | LT-540-717 (compound 32) is a potent FLT3 inhibitor (IC50=0.62 nM) with antiproliferative activity. LT-540-717 also inhibits several acquired FLT3 mutations, FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V). LT-540-717 has potential to be an anti-AML agent[1]. | | References | [1] Zhi Y, et al. Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor. Eur J Med Chem. 2023 Aug 5;256:115448. DOI:10.1016/j.ejmech.2023.115448 |
| | LT-540-717 Preparation Products And Raw materials |
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