ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride

ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride Suppliers list
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Products Intro: Product Name:Ethacizine hydrochloride
CAS:57530-40-2
Purity:98.08% Package:1mg;71USD
Company Name: BOC Sciences
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Products Intro: Product Name:Ethacizine hydrochloride
CAS:57530-40-2
Purity:98% Remarks:Please reach out to us for more information about custom solutions.
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Ethacizine hydrochloride
CAS:57530-40-2
Purity:98.08% Package:1mg;71USD
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Products Intro: Product Name:Ethacizine hydrochloride
CAS:57530-40-2
Purity:98% Package:$140.9/5mg;$230.9/10mg;$480.9/25mg;$760.9/50mg;$1200.9/100mg;Bulk package Remarks:98%
Company Name: ChengDu TongChuangYuan Pharmaceutical Co.Ltd  
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Products Intro: Product Name:Ethacizine hydrochloride
CAS:57530-40-2
Package:1kg

ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride manufacturers
ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride Basic information
Product Name:ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride
Synonyms:ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride;Ethacizin hydrochloride;NIK-244;Ethacizin;10-(N,N-diethyl-β-alanyl)-10H-phenothiazin-2-yl]-carbamic acid ethyl ester hydrochloride
CAS:57530-40-2
MF:C22H28ClN3O3S
MW:0
EINECS:
Product Categories:
Mol File:57530-40-2.mol
ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride Structure
ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride Chemical Properties
form Solid
color White to off-white
Safety Information
MSDS Information
ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride Usage And Synthesis
UsesEthacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent thanFlecainide[1]. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction[2].
in vivo

NIK-244 (1-300 ug) injects directly into the SA node and PM preparations shows negative chronotropic, negative inotropic and coronary vasodilator[1].

References[1] Sugiyama A, et al. Comparison of cardiovascular effects of a novel class Ic antiarrhythmic agent, NIK-244, with those of flecainide in isolated canine heart preparations cross-circulated with a donor dog.Jpn J Pharmacol. 1991 May;56(1):1-12. DOI:10.1254/jjp.56.1
[2] Satoh H, et al. An electrophysiological comparison of a novel class Ic antiarrhythmic agent, NIK-244 (ethacizin) and flecainide in canine ventricular muscle.Br J Pharmacol. 1989 Nov;98(3):827-32.Med Chem.2019 Nov 6:115132. DOI:10.1111/j.1476-5381.1989.tb14611.x
ethyl N-[10-(3-diethylaminopropanoyl)phenothiazin-2-yl]carbamate hydrochloride Preparation Products And Raw materials
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