Benzenesulfonic acid, 2-methyl-, 4-[7-(aminocarbonyl)-1H-benzimidazol-2-yl]-2-bromo-6-methoxyphenyl ester

Benzenesulfonic acid, 2-methyl-, 4-[7-(aminocarbonyl)-1H-benzimidazol-2-yl]-2-bromo-6-methoxyphenyl ester Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:PARP-1-IN-23
CAS:2976497-48-8
Package:50mg;10mg
Benzenesulfonic acid, 2-methyl-, 4-[7-(aminocarbonyl)-1H-benzimidazol-2-yl]-2-bromo-6-methoxyphenyl ester Basic information
Product Name:Benzenesulfonic acid, 2-methyl-, 4-[7-(aminocarbonyl)-1H-benzimidazol-2-yl]-2-bromo-6-methoxyphenyl ester
Synonyms:Benzenesulfonic acid, 2-methyl-, 4-[7-(aminocarbonyl)-1H-benzimidazol-2-yl]-2-bromo-6-methoxyphenyl ester;PARP-1-IN-23
CAS:2976497-48-8
MF:C22H18BrN3O5S
MW:516.37
EINECS:
Product Categories:
Mol File:2976497-48-8.mol
Benzenesulfonic acid, 2-methyl-, 4-[7-(aminocarbonyl)-1H-benzimidazol-2-yl]-2-bromo-6-methoxyphenyl ester Structure
Benzenesulfonic acid, 2-methyl-, 4-[7-(aminocarbonyl)-1H-benzimidazol-2-yl]-2-bromo-6-methoxyphenyl ester Chemical Properties
Boiling point 785.7±70.0 °C(predicted)
density 1.568±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka9.09±0.30(predicted)
Safety Information
MSDS Information
Benzenesulfonic acid, 2-methyl-, 4-[7-(aminocarbonyl)-1H-benzimidazol-2-yl]-2-bromo-6-methoxyphenyl ester Usage And Synthesis
UsesPARP-1-IN-23 (Compound I16 ) is an orally active and selective PARP-1 inhibitor with the IC50 of 12.38 nM. PARP-1-IN-23 inhibits tumor growth in vivo[1].
IC 50PARP-1: 12.38 nM (IC50)
References[1] Zhang Y, et al. Design of Selective PARP-1 Inhibitors and Antitumor Studies. J Med Chem. 2024;67(11):8877-8901. DOI:10.1021/acs.jmedchem.3c02460
Benzenesulfonic acid, 2-methyl-, 4-[7-(aminocarbonyl)-1H-benzimidazol-2-yl]-2-bromo-6-methoxyphenyl ester Preparation Products And Raw materials
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