| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Email: |
eric_feng1954@126.com |
| Products Intro: |
Product Name:SGE-201
CAS:35882-85-0
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:SGE-201
CAS:35882-85-0
Package:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600
|
26,27-Dinorergost-5-ene-3β,24-diol manufacturers
- SGE-201
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- $1980.00
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2026-04-21
- CAS:35882-85-0
- Purity:
- Supply Ability: 10g
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| | 26,27-Dinorergost-5-ene-3β,24-diol Basic information |
| Product Name: | 26,27-Dinorergost-5-ene-3β,24-diol | | Synonyms: | 26,27-Dinorergost-5-ene-3β,24-diol;SGE-201;24,24-dimethyl-cholene-(5)-diol-(3β.24);(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-5-hydroxy-5-methylhexan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;SGE 201,SGE201;26,27-Dinorergost-5-ene-3,24-diol, (3β)- | | CAS: | 35882-85-0 | | MF: | C26H44O2 | | MW: | 388.63 | | EINECS: | | | Product Categories: | | | Mol File: | 35882-85-0.mol |  |
| | 26,27-Dinorergost-5-ene-3β,24-diol Chemical Properties |
| Boiling point | 501.1±23.0 °C(Predicted) | | density | 1.04±0.1 g/cm3(Predicted) | | pka | 15.03±0.70(Predicted) |
| | 26,27-Dinorergost-5-ene-3β,24-diol Usage And Synthesis |
| Description | SGE-201 is a potent allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 is an analogue of an endogenous oxysterol. bSGE-201 increased the actions of memantine and ketamine on phasic excitatory post-synaptic currents, but neither revealed underlying pharmacodynamic differences. SGE-201 accelerated the re-equilibration of blockers during voltage jumps. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by neuroprotection against a mild excitotoxic insult. | | Uses | SGE-201 is an allosteric modulator of N-methyl-D-aspartate receptors (NMDARs), demonstrating significant neuroprotective effects by enhancing NMDAR-mediated responses while differing in action among various blockers in neuronal networks. | | References | [1] The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors DOI:10.1523/JNEUROSCI.2619-13.2013 |
| | 26,27-Dinorergost-5-ene-3β,24-diol Preparation Products And Raw materials |
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