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| | Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Basic information |
| Product Name: | Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride | | Synonyms: | Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride;Cyclohexaneacetic acid, 4-aMino-,ethyl ester (hydrochloride)(1:1), trans-;trans-4-Aminocyclohexaneacetic acid ethyl ester hydrochloride;trans-2-(4-Aminocyclohexyl)acetic acid ethyl ester hydrochloride;Ethyl 2-(trans-4-aminocyclohexyl);ETHYL 2-(4-AMINOCYCLOHEXYL)ACETATE;HYDROCHLORIDE;Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl;Ethyl (trans-4-aminocyclohexyl)acetate hydrochloride (1:1) | | CAS: | 76308-26-4 | | MF: | C10H20ClNO2 | | MW: | 221.73 | | EINECS: | | | Product Categories: | 76308-26-4 | | Mol File: | 76308-26-4.mol |  |
| | Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Chemical Properties |
| Melting point | 177 °C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Sensitive | Air Sensitive,Hygroscopic | | InChI | InChI=1/C10H19NO2.ClH/c1-2-13-10(12)7-8-3-5-9(11)6-4-8;/h8-9H,2-7,11H2,1H3;1H/t8-,9-; | | InChIKey | KBMWRCPPPDEVSJ-JUAUBFSONA-N | | SMILES | C([C@@H]1CC[C@@H](N)CC1)C(=O)OCC.Cl |&1:1,4,r| |
| | Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Usage And Synthesis |
| Uses | Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes. | | Synthesis | 
Preparation of trans 4-amino-cyclohexyl-acetic acid ethyl ester HClA 2500 1 enamelled autoclave is charged with 1000 kg of deionizated water and 210 kg (1.16 kM) of 4-nitrophenyl-acetic acid at room temperature under nitrogen atmosphere. After inertisation by nitrogen to the mixture obtained a suspension of 21 kg of 10% Pd/C in 20 kg of deionized water is added and the catalyst measuring gauge is rinsed by additional 20 kg of deionizated water. After rinsing the reaction vessel by hydrogen gas the hydrogenation is carried out at a temperature between 44-46C and under up to 0,6 bar overpressure until the hydrogen uptake is slowed. After reducing the nitro group the temperature is brought to 55- 58C and the hydrogenation continued maintaining hydrogen pressure on max. 4.0 bar overpressures. After completion of the hydrogen uptake, the mixture is cooled to a temperature between 25-30C, purged with nitrogen and the catalyst is filtered on a Spakler filter under pressurized nitrogen. The reaction vessel, the filter and the lines are washed additional 200 g of deionized water. The filtrates are combined and in a 2500 1 enamelled doubler 1200 kg of distillate is distilled at up to 80C inner temperature in vacuum. The residue obtained is cooled to a temperature below 30C and 430 kg of ethyl alcohol is added, then 500 1 of distillate is collected at up to 80C under vacuum. After completion of the distillation the mixture is cooled to a temperature between 25-30C, (water content is max. 10 w%, in terms of absolute value is about 32 kg), and 550 kg of ethyl alcohol, then 170 kg of 30% hydrochloric ethyl alcohol are added and the reaction mixture is heated to reflux for approx. 2 hours. When the esterification is complete 800 1 of solvent is distilled off at up to 80C, under vacuum. Additional 800 1 of ethyl alcohol is added and further 750-800 1 of solvent is distilled off at up to 80C, under vacuum. To the residue obtained 700 kg of acetonitrile is added and 140 1 of distillate is collected at up to 80C under vacuum. The vacuum is stopped by introducing nitrogen and the solution is cooled to a temperature between 0-(-)5C. The crystals obtained is centrifuged, washed with 100 kg of acetonitrile in two portions during which the temperature is kept at 0-(-)5C. The solid obtained is dried to a constant weight at up to 6O0C. In this manner 90 kg of title product is obtained. Yield: 40 %. Melting point: 173-1760C. | | References | [1] Patent: WO2010/70368, 2010, A1. Location in patent: Page/Page column 4
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980, vol. 29, p. 1689 - 1694
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980, # 10, p. 2374 - 2379 |
| | Ethyl trans-2-(4-Aminocyclohexyl)acetate Hydrochloride Preparation Products And Raw materials |
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