Benzoic acid, 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-, Methyl ester manufacturers
- Ataluren Impurity
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2025-12-16
- CAS:775304-60-4
- Min. Order: 10mg
- Purity: 99%+ HPLC
- Supply Ability: 1000
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| | Benzoic acid, 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-, Methyl ester Basic information |
| Product Name: | Benzoic acid, 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-, Methyl ester | | Synonyms: | Benzoic acid, 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-, Methyl ester;Methyl 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoate;3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-Benzoic acid Methyl ester;Ataluren impurity C;Ataluren impurities6;Thiocoraline Impurity12;Ataluren Impurity 6 | | CAS: | 775304-60-4 | | MF: | C16H11FN2O3 | | MW: | 298.27 | | EINECS: | 837-181-8 | | Product Categories: | | | Mol File: | 775304-60-4.mol | ![Benzoic acid, 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-, Methyl ester Structure](CAS/GIF/775304-60-4.gif) |
| | Benzoic acid, 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-, Methyl ester Chemical Properties |
| Boiling point | 457.2±55.0 °C(Predicted) | | density | 1.289±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -3.63±0.50(Predicted) | | Appearance | White to off-white Solid |
| | Benzoic acid, 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-, Methyl ester Usage And Synthesis |
| Synthesis | GENERAL METHOD: 2 mmol of methyl (E)-3-(N'-hydroxycarbamoyl)benzoate was dissolved in 200 mL of acetone in a round-bottomed flask; subsequently, 0.35 g (2.5 mmol) of K2CO3 and 2.5 mmol of o-fluorobenzoyl chloride were added to the reaction mixture, and the reaction was stirred for 24 h at room temperature. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was treated with an appropriate amount of water and refluxed for 30 minutes. After the reaction mixture was cooled, the 1,2,4-oxadiazole product was collected by filtration and further purified by column chromatography to afford the target compound, methyl 3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoate. | | References | [1] European Journal of Medicinal Chemistry, 2015, vol. 101, p. 236 - 244
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 11, p. 2473 - 2476 |
| | Benzoic acid, 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-, Methyl ester Preparation Products And Raw materials |
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