| Company Name: |
Shanghai JONLN Reagent Co., Ltd.
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400-0066400 13621662912 |
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422131432@qq.com |
| Products Intro: |
Product Name:A770041
CAS:869748-10-7
Purity:NULL Package:5MG;
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| Company Name: |
SPIRO PHARMA
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eric_feng1954@126.com |
| Products Intro: |
Product Name:A-770041
CAS:869748-10-7
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
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| | A-770041 Basic information |
| Product Name: | A-770041 | | Synonyms: | A-770041;N-(4-(1-((1r,4r)-4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide;N-[4-[1-[trans-4-(4-Acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-1H-indole-2-carboxamide;N-[4-[1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methylindole-2-carboxamide;1H-Indole-2-carboxamide, N-[4-[1-[trans-4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-;selective,concanavalin A,inhibit,acute rejection,Src,IL-2,Inhibitor,T cell,rat,small-molecule,A 770041,A770041,A-770041;N-(4-(1-(trans-4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide;N-(4-(1-(trans-4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide?, A-770041 | | CAS: | 869748-10-7 | | MF: | C34H39N9O3 | | MW: | 621.73 | | EINECS: | | | Product Categories: | | | Mol File: | 869748-10-7.mol |  |
| | A-770041 Chemical Properties |
| Boiling point | 812.6±65.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | 0.1 M HCl: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml | | pka | 13.21±0.70(Predicted) | | form | Powder | | color | White to off-white |
| | A-770041 Usage And Synthesis |
| Uses | A-770041 is a selective and orally active Src-family Lck inhibitor. A-770041 inhibits Lck with an IC50 value of 147 nM with the presence of 1 mM ATP. A-770041 shows 300-fold selective to Lck over Fyn, the other Src family kinase involved in T-cell signaling. A-770041 can be used for the research of acute rejection[1][2]. | | Definition | ChEBI: N-[4-[1-[4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-3-pyrazolo[3,4-d]pyrimidinyl]-2-methoxyphenyl]-1-methyl-2-indolecarboxamide is an aromatic amide. | | in vivo | A-770041 (2.5 mg/kg; i.g. once) inhibits concanavalin A-induced IL-2 in vivo[1].
A-770041 (2.5-20 mg/kg/day; for 14 days) dose-dependently increases the survival rate with doses of 5 and 10 mg/kg/day, and survives 100% of transplanted grafts until 14 days with doses of 10 and 20 mg/kg/day[1]. | Animal Model: | Male Lewis rats[1] | | Dosage: | 2.5 mg/kg | | Administration: | Intragastric administration; 2.5 mg/kg once | | Result: | Showed an inhibition of concanavalin A-induced IL-2 with an in vivo EC50 value of 78 nM. |
| | References | [1] Stachlewitz RF, et al.A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection.J Pharmacol Exp Ther. 2005 Oct;315(1):36-41. DOI:10.1124/jpet.105.089169
[2] Andrew Burchat, et al. Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection Bioorganic & Medicinal Chemistry Letters Volume 16, Issue 1, 1 January 2006, Pages 118-122 DOI:10.1016/j.bmcl.2005.09.039 |
| | A-770041 Preparation Products And Raw materials |
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