1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) manufacturers
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| | 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) Basic information |
| Product Name: | 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) | | Synonyms: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHO-L-SERINE (SODIUM SALT);18:1 PS (DOPS);1,2-Dioleoyl-sn-glycero-3-PS (sodium salt);sodium O-(((R)-2,3-bis(oleoyloxy)propoxy)oxidophosphoryl)-L-serinate;(2S)-2-azaniumyl-3-[[(2R)-2,3-bis[[(Z)-octadec-9-enoyl]oxy]propoxy]-oxidophosphoryl]oxypropanoate;18:1 PS (DOPS);1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium;1,2-Dioctadecenoyl-sn-glycero-3-Phosphoserine;Inhibitor,1,2 Dioleoyl sn glycero 3 phospho L serine sodium,DOPE,inhibit,1,2Dioleoylsnglycero3phosphoLserine sodium,DOPC | | CAS: | 90693-88-2 | | MF: | C42H79NNaO10P | | MW: | 812.05 | | EINECS: | | | Product Categories: | | | Mol File: | 90693-88-2.mol |  |
| | 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Chloroform: 10 mg/ml | | form | A crystalline solid | | color | Light yellow to orange | | Water Solubility | soluble (Insoluble in ethanol and DMSO, soluble in Chloroform:Methanol:Water (65:25:4) at 5mg/mL) | | InChIKey | RRLDZFIFYLDDLI-OLZOWLLTNA-N | | SMILES | [C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)(OC(=O)CCCCCCC/C=C\CCCCCCCC)COP(O)(=O)OC[C@H](N)C(=O)O.[NaH] |&1:0,49,r| |
| WGK Germany | WGK 3 | | Storage Class | 13 - Non Combustible Solids |
| | 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) Usage And Synthesis |
| Description | 1,2-Dioleoyl-sn-glycero-3-PS (DOPS) is a phospholipid containing oleic acid (Item Nos. 90260 | 24659) at the sn-1 and sn-2 positions, respectively. Nanovesicles composed of DOPS and the lysosomal protein saposin C (SapC) are cytotoxic to SK-MEL-28 cells in vitro and decrease tumor volume in a squamous cell carcinoma mouse xenograft model. DOPS has been used in the formation of unilamellar vesicles to study the effect of curvature on membrane structure and in the formation of supported lipid bilayers to study the effects of various support materials on lipid redistribution between membrane leaflets. | | Uses |
1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) is a lipid being studied in the assembly and long-term stability of solid supported lipid bilayers from artificial and natural lipid mixtures.
| | References | [1] SHADI ABU-BAKER. Cytotoxicity and Selectivity in Skin Cancer by SapC-DOPS Nanovesicles.[J]. Journal of Cancer Therapy, 2012, 3 4: 321-326. DOI: 10.4236/jct.2012.34041
[2] NORBERT KUERKA. Curvature Effect on the Structure of Phospholipid Bilayers[J]. Langmuir, 2006, 23 3: 1292-1299. DOI: 10.1021/la062455t
[3] RALF P. RICHTER Alain R B Nicolas Maury. On the Effect of the Solid Support on the Interleaflet Distribution of Lipids in Supported Lipid Bilayers[J]. Langmuir, 2004, 21 1: 299-304. DOI: 10.1021/la0478402 |
| | 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) Preparation Products And Raw materials |
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