- COOH-PEG4-COOMe
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2025-06-07
- CAS:2028284-75-3
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | Acid-PEG4-mono-methyl ester Basic information |
| Product Name: | Acid-PEG4-mono-methyl ester | | Synonyms: | Acid-PEG4-mono-methyl ester;acid-PEG3-methyl ester;CAS_2028284-75-3;4,7,10,13-Tetraoxahexadecanedioic acid, 1-methyl ester;MeOOCCH2CH2O-PEG3-CH2CH2COOH;Acid-PEG4-Methyl Ester;MeOOCCH2CH2O-PEG3-CH2CH2COOH/4,7,10,13-Tetraoxahexadecanedioic acid, 1-methyl ester;3-[2-[2-[2-(3-methoxy-3-oxo-propoxy)ethoxy]ethoxy]ethoxy]propanoic acid | | CAS: | 2028284-75-3 | | MF: | C13H24O8 | | MW: | 308.32486 | | EINECS: | | | Product Categories: | | | Mol File: | 2028284-75-3.mol |  |
| | Acid-PEG4-mono-methyl ester Chemical Properties |
| Boiling point | 433.8±40.0 °C(Predicted) | | density | 1.156±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 4.28±0.10(Predicted) | | form | Liquid | | color | Light yellow to yellow |
| | Acid-PEG4-mono-methyl ester Usage And Synthesis |
| Description | Acid-PEG4-mono-methyl ester is a PEG linker with a carboxylic acid and methyl ester group. Methyl ester can be hydrolyzed under strong basic condition. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | | Uses | Acid-PEG4-mono-methyl ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] Kanazaki K, et al. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23. DOI:10.1016/j.jconrel.2016.02.017 |
| | Acid-PEG4-mono-methyl ester Preparation Products And Raw materials |
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