N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt

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Products Intro: Product Name:N-(Propargyl-PEG4)-N-bis(PEG4-acid)
CAS:2093153-09-2
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:N-(Propargyl-PEG4)-N-bis(PEG4-acid)
CAS:2093153-09-2
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Products Intro: Product Name:N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt
CAS:2093153-09-2
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Products Intro: Product Name:N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt
CAS:2093153-09-2
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Products Intro: Product Name:N-(Propargyl-PEG4)-N-bis(PEG4-acid)
CAS:2093153-09-2
Purity:95.00% Package:250mg;500mg;1g
N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt Basic information
Product Name:N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt
Synonyms:N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt;N-(Propargyl-peg4)-n-bis(peg4-acid);QUN 53092;4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)-;N-(Propargyl-peg4)-n-bis(peg4-acid) hydrochloride
CAS:2093153-09-2
MF:C33H61NO16
MW:727.83
EINECS:
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Mol File:2093153-09-2.mol
N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt Structure
N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt Chemical Properties
Boiling point 765.0±60.0 °C(Predicted)
density 1.155±0.06 g/cm3(Predicted)
solubility Soluble in Water, DMSO, DCM, DMF
pka3.97±0.10(Predicted)
Safety Information
MSDS Information
N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt Usage And Synthesis
DescriptionN-(Propargyl-PEG4)-N-bis(PEG4-acid) is a branched crosslinking reagent with a propargyl group and two terminal carboxylic acids. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acids can react with primary amino groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
UsesN-(Propargyl-PEG4)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt Preparation Products And Raw materials
Tag:N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt(2093153-09-2) Related Product Information
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