2-(N-7-硝基-2,1,3-苯并惡二唑-4-氨基)-2-脫氧-D-葡萄糖
| 中文名稱 | 2-(N-7-硝基-2,1,3-苯并惡二唑-4-氨基)-2-脫氧-D-葡萄糖 |
|---|---|
| 中文同義詞 | 2-(N-7-硝基-2,1,3-苯并惡二唑-4-氨基)-2-脫氧-D-葡萄糖;2-脫氧-2-[(7-硝基-2,1,3-苯并惡二唑-4-基)氨基]-D-葡萄糖;2-(N-7-硝基-2,1,3-苯并噁二唑-4-氨基)-2-脫氧-D-葡萄糖, 混合物;葡萄糖轉(zhuǎn)運(yùn)/血糖通道熒光探針2-NBDG;2-(N-7-硝基-2,1,3-苯并噁二唑-4-氨基)-2-脫氧-D-葡萄糖;葡萄糖攝取熒光探針;(2R,3R,4S,5R)-3,4,5,6-四羥基-2-((7-硝基苯并[C][1,2,5]惡二唑-4-基)氨基)己醛;2-NBDG, 2-(N-7-硝基-2,1,3-苯并惡二唑-4-氨基)-2-脫氧-D-葡萄糖 |
| 英文名稱 | 2-(N-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)AMINO)-2-DEOXYGLUCOSE |
| 英文同義詞 | 2-(N-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)AMINO)-2-DEOXYGLUCOSE;2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose;2-NBDG min. 95%;2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose, 90%, mixed Isomers;2-NBD-Glucose;2-NBDG [2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose] *CAS#: 186689-07-6*;2-NBDG,2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose;NBD-GLUCOSE |
| CAS號(hào) | 186689-07-6 |
| 分子式 | C12H14N4O8 |
| 分子量 | 342.26 |
| EINECS號(hào) | |
| 相關(guān)類別 | 糖;穩(wěn)定性同位素;其他生化試劑;化合物;生化試劑 |
| Mol文件 | Mol File |
| 結(jié)構(gòu)式 |  |
2-(N-7-硝基-2,1,3-苯并惡二唑-4-氨基)-2-脫氧-D-葡萄糖 性質(zhì)
| 熔點(diǎn) | 137 - 140°C |
|---|---|
| 沸點(diǎn) | 740.0±70.0 °C(Predicted) |
| 密度 | 1.750±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 溶于DMSO（高達(dá)10mg/ml）。 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 12.96±0.20(Predicted) |
| 顏色 | 深黃色至橙色/紅色 |
| 生物來源 | synthetic |
| BRN | 7603370 |
| 穩(wěn)定性 | 可在-20°下的DMSO中的溶液儲(chǔ)存長達(dá)1個(gè)月。 |
| InChI | InChI=1S/C12H14N4O8/c17-3-6(11(20)12(21)8(19)4-18)13-5-1-2-7(16(22)23)10-9(5)14-24-15-10/h1-3,6,8,11-13,18-21H,4H2/t6-,8+,11+,12+/m0/s1 |
| InChIKey | QUTFFEUUGHUPQC-ILWYWAAHSA-N |
| SMILES | O=C[C@H](NC1C2C(C([N+]([O-])=O)=CC=1)=NON=2)[C@H]([C@@H]([C@@H](CO)O)O)O |
2-NBDG，一種熒光脫氧葡萄糖衍生物，是檢測葡萄糖攝取的標(biāo)志物，也用于檢測細(xì)胞活力。
It has since been demonstrated in living mammalian cells that the uptake of 2-NBDG takes place through glucose transporters (GLUTs) in a concentration-, time- and temperature-dependent manner. A short-period application of 2-NBDG produced a remarkable increase in the fluorescence intensity in COS-1 cells over-expressing GLUT2, whereas the increase was barely detectable in mock-transfected cells. In mouse insulin-secreting clonal MIN6 cells, uptake was inhibited by cytochalasin B, a specific blocker for GLUTs, and by D-glucose in a dose-dependent manner.
安全信息
| WGK Germany | 3 |
|---|---|
| 海關(guān)編碼 | 2934999090 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | S8914 | 2-(N-7-硝基-2,1,3-苯并惡二唑-4-氨基)-2-脫氧-D-葡萄糖 2-NBDG | 186689-07-6 | 5mg | 2448.81元 |
| 2026/07/06 | S8914 | 2-(N-7-硝基-2,1,3-苯并惡二唑-4-氨基)-2-脫氧-D-葡萄糖 2-NBDG | 186689-07-6 | 10mM (1mL in DMSO) | 2858.31元 |