5-膽甾烯-3Β,25-二醇
| 中文名稱 | 5-膽甾烯-3Β,25-二醇 |
|---|---|
| 中文同義詞 | 25-羥基膽甾醇;5-膽甾烯-3Β,25-二醇;25-羥基膽固醇;25-二醇;5-膽甾烯-3Β;25-羥基膽固醇 標(biāo)準(zhǔn)品;(3S,8S,9S,10R,13R,14S,17R)-17-[(R)-6-羥基-6-甲基-2-庚基]-10,13-二甲基-2,3,4,7,8,9,10,11,12,13,14,15,16,17-十四氫-1H-環(huán)戊并[A]菲-3-醇;(3S,8S,9S,10R,13R,14S,17R)-17-((R)-6-羥基-6-甲基庚-2-基)-10,13-二甲基-2,3,4,7,8,9,10,11,12,13,14,15,16,17-十四氫-1H-環(huán)戊二烯并[A]菲-3-醇 |
| 英文名稱 | 25-HYDROXYCHOLESTEROL |
| 英文同義詞 | 3BETA,25-DIHYDROXY-5-CHOLESTENE;5-CHOLESTEN-3-BETA, 25-DIOL;5-CHOLESTENE-3BETA,25-DIOL;25-Hydroxycholesterol (not deuterated);Cholest-5-ene-3,25-diol, (3.beta.)-;5-cholestene-3β,25-diol;(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;3β,25-Dihydroxycholest-5-ene |
| CAS號(hào) | 2140-46-7 |
| 分子式 | C27H46O2 |
| 分子量 | 402.65 |
| EINECS號(hào) | 218-362-5 |
| 相關(guān)類別 | 脂類;有機(jī)化學(xué);化工原料;試劑盒-細(xì)胞分析試劑盒;對(duì)照品;Hydroxycholesterol;Apoptosis;Inhibitors;Intermediates & Fine Chemicals;Metabolites & IMpurities;Pharmaceuticals;Steroids |
| Mol文件 | 2140-46-7.mol |
| 結(jié)構(gòu)式 |  |
5-膽甾烯-3Β,25-二醇 性質(zhì)
| 熔點(diǎn) | 177-179 °C |
|---|---|
| 沸點(diǎn) | 513.1±23.0 °C(Predicted) |
| 密度 | 1.03±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | -20°C |
| 溶解度 | 氯仿：50 mg/mL，澄清，無色至淡黃色 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 15.03±0.70(Predicted) |
| 顏色 | 白色或淡黃色 |
| 生物來源 | synthetic (organic) |
| Merck | 13,4846 |
| BRN | 3161259 |
| 穩(wěn)定性 | 可在-20°下的DMSO或乙醇溶液保存長達(dá)3個(gè)月。 |
| InChIKey | INBGSXNNRGWLJU-ZHHJOTBYSA-N |
| SMILES | [C@@]12([H])CC[C@H]([C@H](C)CCCC(O)(C)C)[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@H](O)CC3=CC[C@@]21[H] |&1:0,4,5,14,18,20,24,30,r| |
25-Hydroxycholesterol 是膽固醇的代謝產(chǎn)物，由巨噬細(xì)胞響應(yīng) Toll 樣受體 (TLR) 激活而產(chǎn)生和分泌。25-Hydroxycholesterol 有效且選擇性抑制 B 細(xì)胞產(chǎn)生 IgA，EC50 約為 65 nM。
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Human Endogenous Metabolite
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The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems.
安全信息
| 危險(xiǎn)品標(biāo)志 | Xn |
|---|---|
| 危險(xiǎn)類別碼 | 20/21/22-36/37/38-48 |
| 安全說明 | 26-36-45 |
| WGK Germany | 3 |
| 海關(guān)編碼 | 29062990 |
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 提供商 | 語言 |
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英文
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