TP-472

TP-472 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:TP-472
CAS:2079895-62-6
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:TP-472
CAS:2079895-62-6
Package:5mg;468USD|1mg;108USD
Company Name: Sichuan Wei Keqi Biological Technology Co., Ltd.  
Tel: 028-81700200 18116577057
Email: 3003855609@qq.com
Products Intro: Product Name:TP-472
CAS:2079895-62-6
Purity:HPLC≥98% Package:20mg/10
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Products Intro: Product Name:TP-472
CAS:2079895-62-6
Purity:98% HPLC Package:1g
Company Name: BOC Sciences  
Tel: 16314854226
Email: info@bocsci.com
Products Intro: Product Name:TP-472
CAS:2079895-62-6
Purity:98% Package:1G;10G;100G Remarks:TP-472 is an inhibitor of bromodomain BRD9 and BRD7 bromodomain with Kd values of 33 and 340 nM, respectively.

TP-472 manufacturers

  • TP-472
  • TP-472 pictures
  • $226.00
  • 2026-07-10
  • CAS:2079895-62-6
  • Purity:
  • Supply Ability: 10g
TP-472 Basic information
Product Name:TP-472
Synonyms:TP-472;TP472,TP 472;Benzamide, 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methyl-
CAS:2079895-62-6
MF:C20H19N3O2
MW:333.38
EINECS:
Product Categories:
Mol File:2079895-62-6.mol
TP-472 Structure
TP-472 Chemical Properties
density 1.31±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: Soluble
form A solid
pka14.98±0.20(Predicted)
color Light yellow to yellow
InChI1S/C20H19N3O2/c1-12-4-5-14(20(25)22-15-6-7-15)10-16(12)17-11-18(13(2)24)23-9-3-8-21-19(17)23/h3-5,8-11,15H,6-7H2,1-2H3,(H,22,25)
InChIKeyRPBMXJHQYJLPDN-UHFFFAOYSA-N
SMILESO=C(C)C1=CC(C2=C(C)C=CC(C(NC3CC3)=O)=C2)=C4N=CC=CN41
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
TP-472 Usage And Synthesis
DescriptionTP-472 is an inhibitor of bromodomain BRD9 (Kd = 33 nM; EC50 = 320 nM in a NanoBRET assay). It has >30-fold selectivity over all other bromodomain family members with the exception of the highly homologous BRD7 bromodomain (Kd = 340 nM in an isothermal titration calorimetry (ITC) assay). See the Structural Genomic Consortium (SGC) website for more information.
UsesTP-472 is a selective BRD9/7 inhibitor, with Kds of 33 nM and 340 nM for BRD9 and BRD7, respectively. TP-472 exhibits >30-fold selectivity for BRD9 over other bromodomain family members except BRD7[1][2]. TP-472 induces apoptosis of melanoma cells[3].
in vivo

TP-472 (20 mg/kg; i.p.; three times a week; for 5 weeks) significantly inhibits the subcutaneous tumor growth in melanoma xenograft mouse model[3].

Animal Model:NSG mice injected with A375-MA2 cells (male five- to six-week-old)[3]
Dosage:20 mg/kg
Administration:i.p.; three times a week; for 5 weeks
Result:Significantly inhibited the subcutaneous tumor growth in melanoma xenograft mouse model.
IC 50BRD9: 33 nM (Kd); BRD7: 0.34 μM (Kd)
storageStore at -20°C
References[1] Moustakim M, et al. Chemical probes and inhibitors of bromodomains outside the BET family. Medchemcomm. 2016 Dec 7;7(12):2246-2264. DOI:10.1039/c6md00373g
[2] Gatchalian J, et al. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Nat Commun. 2018 Dec 3;9(1):5139. DOI:10.1038/s41467-018-07528-9
[3] Lawrence David Mason, et al. The BRD9/7 Inhibitor TP-472 Blocks Melanoma Tumor Growth by Suppressing ECM-Mediated Oncogenic Signaling and Inducing Apoptosis. Cancers (Basel). 2021 Nov 3;13(21):5516. DOI:10.3390/cancers13215516
TP-472 Preparation Products And Raw materials
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