| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 15002144251 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CGS 15435
CAS:95853-92-2
Purity:99.86% Package:1mg/RMB 580;5mg/RMB 1400;10mg/RMB 1960
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CGS 15435 manufacturers
- CGS 15435
-
- $83.00
-
2026-05-11
- CAS:95853-92-2
- Purity: 99.86%
- Supply Ability: 10g
- CGS 15435
-
- $83.00
-
2026-05-11
- CAS:95853-92-2
- Purity: 99.86%
- Supply Ability: 10g
|
| | CGS 15435 Basic information |
| Product Name: | CGS 15435 | | Synonyms: | CGS 15435;1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-;CGS 15435, 10 mM in DMSO | | CAS: | 95853-92-2 | | MF: | C20H21ClN2O2 | | MW: | 356.85 | | EINECS: | | | Product Categories: | | | Mol File: | 95853-92-2.mol |  |
| | CGS 15435 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | CGS 15435 Usage And Synthesis |
| Uses | CGS 15435, is a thromboxane (TxA2) synthetase inhibitor. It has also high selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. | | in vivo | CGS 15435 has a long duration of action, since the increases in the plasma levels of TxB2 are prevented even at 24 h after CGS 15435 administration. CGS 15435 significantly inhibits TxB2 formation 4, 6, 12 and 24 h after dosing. Administration of CGS 15435 0.25 or 24 h prior to Arachidonic acid (AA) produced no increase in TxB2 in the surviving animals (4/4 and 5/6, respectively). The final TxB2 levels in the CGS15435A (0.25 and 24 h pretreatment) groups are significantly lower (P<0.05) than those seen in the AA or the Dazoxiben (2 h pretreatment) groups[1]. | | IC 50 | TXA2: 1 nM (IC50) |
| | CGS 15435 Preparation Products And Raw materials |
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