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| | RO 90-7501 Basic information |
| Product Name: | RO 90-7501 | | Synonyms: | 2'-(4-aMinophenyl)-1H,3'H-2,5'-bibenzo[d]iMidazol-6-aMine;RO90-7501; RO 907501;2'-(4-Aminophenyl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-5-amine;2,5'-Bi-1H-benzimidazol]-5-amine, 2'-(4-aminophenyl)- | | CAS: | 293762-45-5 | | MF: | C20H16N6 | | MW: | 340.388 | | EINECS: | | | Product Categories: | | | Mol File: | 293762-45-5.mol |  |
| | RO 90-7501 Chemical Properties |
| storage temp. | Store at +4°C | | solubility | DMSO: ~20mg/mL | | form | solid | | color | brown |
| | RO 90-7501 Usage And Synthesis |
| Uses | Ro 90-7501 exhibits antibacterial activity. In addition, it also promote both toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. | | Definition | ChEBI: 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine is a member of benzimidazoles. | | Biological Activity | Inhibitor of amyloid β 42 (A β 42) fibril assembly; reduces A β 42-induced toxicity (EC 50 = 2 μ M). | | in vivo | Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment significantly delays tumor growth and significantly decreases tumor volume[1]. | Animal Model: | Female BALB/c nude mice (8-week-old) with HeLa cells under irradiation[1] | | Dosage: | 5 μg/g | | Administration: | Intraperitoneal injection; daily; for 21 days | | Result: | Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.
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| | IC 50 | Amyloid β42; ATM; Protein phosphatase 5; Apoptosis | | storage | Store at +4°C |
| | RO 90-7501 Preparation Products And Raw materials |
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