- CD437
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- $34.00
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2026-05-11
- CAS:125316-60-1
- Purity: 99.56%
- Supply Ability: 10g
- CD 437
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- $1.00
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2020-01-13
- CAS:125316-60-1
- Min. Order: 1g
- Purity: 95-99%
- Supply Ability: 1ton
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| Product Name: | CD437 | | Synonyms: | 2-naphthalenecarboxylicacid,6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphen;6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-2-naphthalenecarboxylic;AHPN, 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid;O-DesMethyl Adapalene;CD 437/AHPN;Adapalene IMpurity F;Apoptosis Activator VI, CD437/AHPN;ADAP-IME | | CAS: | 125316-60-1 | | MF: | C27H26O3 | | MW: | 398.49 | | EINECS: | 200-258-5 | | Product Categories: | Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 125316-60-1.mol |  |
| | CD437 Chemical Properties |
| Melting point | 271.6-276 °C | | Boiling point | 595.0±50.0 °C(Predicted) | | density | 1.290 | | storage temp. | -20°C | | solubility | DMSO: 26 mg/mL | | form | solid | | pka | 4.17±0.30(Predicted) | | color | yellow | | InChI | 1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30) | | InChIKey | LDGIHZJOIQSHPB-UHFFFAOYSA-N | | SMILES | OC(=O)c1ccc2cc(ccc2c1)-c3ccc(O)c(c3)C45CC6CC(CC(C6)C4)C5 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | QJ1975900 | | Storage Class | 11 - Combustible Solids |
| | CD437 Usage And Synthesis |
| Chemical Properties | Yellow Solid | | Uses | An intermediate in the preparation of Adapalene derivatives. | | Definition | ChEBI: A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)g
mma and induces cell cycle arrest and apoptosis in various cancer cells. | | Biological Activity | Synthetic retinoid that is an RAR γ -selective agonist. Displays RAR γ -dependent and -independent effects on differentiation and apoptosis. | | Biochem/physiol Actions | CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis. | | storage | Store at -20°C |
| | CD437 Preparation Products And Raw materials |
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