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| | 2-(2,4-DIFLUOROPHENYL)PYRIDINE Basic information |
| | 2-(2,4-DIFLUOROPHENYL)PYRIDINE Chemical Properties |
| density | 1.254 g/mL at 25 °C | | refractive index | n20/D1.570 | | Fp | 103℃ | | storage temp. | Inert atmosphere,Room Temperature | | form | crystal | | pka | 3.91±0.25(Predicted) | | color | white | | Boiling point | 95°C/0.4 mmHg | | InChI | 1S/C11H7F2N/c12-8-4-5-9(10(13)7-8)11-3-1-2-6-14-11/h1-7H | | InChIKey | SSABEFIRGJISFH-UHFFFAOYSA-N | | SMILES | Fc1ccc(c(F)c1)-c2ccccn2 |
| Hazard Codes | Xn | | Risk Statements | 22-37/38-41-36/37/38 | | Safety Statements | 26-39-24/25 | | WGK Germany | 3 | | TSCA | No | | HS Code | 29333990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 2-(2,4-DIFLUOROPHENYL)PYRIDINE Usage And Synthesis |
| Chemical Properties | Colorless to dark yellow liquid | | Uses | Ligand used in a blue-light emitting Ir(III) complexes suitable for use as phosphorescent OLEDs. | | Synthesis | General procedure for the synthesis of 2-(2,4-difluorophenyl)pyridine from 2-bromopyridine and 2,4-difluorophenylboronic acid: 2-bromopyridine (2.01 mL, 21.1 mmol), 2,4-difluorophenylboronic acid (4.00 g, 25.3 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.732 g, 0.633 mmol) were added to a reflux condenser equipped with a round bottom flask and dissolved in 50 mL of tetrahydrofuran (THF). Subsequently, 30 mL of 2 M sodium carbonate (Na2CO3) aqueous solution was added to the reaction system. The reaction mixture was heated to reflux at 70°C for 24 hours. After completion of the reaction, it was cooled to room temperature and the crude reaction mixture was poured into water and extracted with dichloromethane (CH2Cl2, 50 mL x 3). The organic phases were combined and dried with anhydrous magnesium sulfate. Purification by silica gel column chromatography (eluent: n-hexane/ethyl acetate=4:1, v/v) afforded the target product 2-(2,4-difluorophenyl)pyridine (dfppy 1) as a colorless liquid (3.90 g, 97% yield). | | References | [1] Journal of the American Chemical Society, 2005, vol. 127, # 36, p. 12438 - 12439
[2] Inorganic Chemistry, 2017, vol. 56, # 19, p. 11565 - 11576
[3] Patent: US2012/273765, 2012, A1. Location in patent: Page/Page column 23-24
[4] Chemical Science, 2016, vol. 8, # 1, p. 348 - 360
[5] Patent: US2006/237715, 2006, A1. Location in patent: Page/Page column 11; 13 |
| | 2-(2,4-DIFLUOROPHENYL)PYRIDINE Preparation Products And Raw materials |
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