| Company Name: |
Novus Biologicals
|
| Tel: |
400821347 |
| Email: |
orders@novusbio.com |
| Products Intro: |
Product Name:DDX21 Antibody
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| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Email: |
Enzoname@qq.com |
| Products Intro: |
Product Name:DDX21 Antibody
|
| Company Name: |
Biosynth Ltd
|
| Tel: |
18886812933 |
| Email: |
sales@biosynth.com |
| Products Intro: |
Product Name:DDX21 antibody
|
| Company Name: |
Abmart Inc
|
| Tel: |
4006-123-828 13162017139 |
| Email: |
market@ab-mart.com |
| Products Intro: |
Product Name:DDX21 Antibody
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| | DDX21 antibody Chemical Properties |
| | DDX21 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | DDX21, also known as RNA helicase II/Gu, is an RNA helicase that plays important roles in transcription and ribosomal RNA processing. DDX21 associates with many RNA Polymerase I and II genes, including the direct binding to the rDNA locus to promote ribosome biogenesis. The helicase activity of DDX21 contributes to transcription by helping release P-TEFb from the 7SK small nuclear ribonucleoprotein complex. Nucleolar localization of DDX21 has been shown to be regulated through phosphorylation by JNK and interaction with c-Jun. Depletion of either c-Jun or JNK has shown to impair rRNA processing. DDX21 can also become acetylated by CBP, which reduces its activity. Deacetylation by SIRT7 increases DDX21 helicase activity to prevent R-loop accumulation and protect genomic stability. DDX21 can also form a complex with DDX1, DHX36, and TRIF to sense dsRNA, which in turn activates interferon response in innate immunity. | | References | [1] Yang, H. et al. (2003) J Biol Chem 278, 38847-59.
[2] Henning, D. et al. (2003) J Biol Chem 278, 52307-14.
[3] Calo, E. et al. (2015) Nature 518, 249-53.
[4] Holmstr?m, T.H. et al. (2008) J Biol Chem 283, 7046-53.
[5] Mialon, A. et al. (2008) FEBS Lett 582, 3145-51.
[6] Song, C. et al. (2017) Genes Dev 31, 1370-1381.
[7] Zhang, Z. et al. (2011) Immunity 34, 866-878.
[8] Tsai, S.Y. et al. (2014) PLoS Pathog 10, e1003848. |
| | DDX21 antibody Preparation Products And Raw materials |
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